Citation: Huan Li, Yuxuan Han, Zi Yang, Zhenyu Yao, Lianhui Wang, Xiuling Cui. Rh(Ⅲ)-catalyzed annulation of azobenzenes and α-Cl ketones toward 3-acyl-2H-indazoles[J]. Chinese Chemical Letters, ;2021, 32(5): 1709-1712. doi: 10.1016/j.cclet.2020.12.027 shu

Rh(Ⅲ)-catalyzed annulation of azobenzenes and α-Cl ketones toward 3-acyl-2H-indazoles

Engineering Research Centre of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medi-cine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China

cuixl@hqu.edu.cn

Received Date: 8 October 2020
Revised Date: 16 December 2020
Accepted Date: 17 December 2020
Available Online: 20 December 2020

Figures(5)

Rhodium(Ⅲ)-catalyzed [4 + 1] cyclization of azobenzenes with α-Cl ketones has been developed. 3-Acyl-2H-indazoles could be easily afforded in up to 97% yields for more than 30 examples. The obtained products are potentially valuable in organic synthesis and drug discovery. This protocol featured with high efficiency, extensive functional group tolerance and mild reaction conditions. The one-step efficient construction of an anti-inflammatory agent confirms the practicability of this procedure.
- Rh(Ⅲ)-catalyzed,
- C-H activation/cyclization,
- α-Cl Ketones,
- 3-Acyl-2H-indazoles
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