Citation: Chunmeng Ma, Jinlong Zhang, Yuan Zhang, Chen Ma, Minrui Ma, Fanpeng Ran, Xiaoyan Liu, Haixia Zhang. Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis[J]. Chinese Chemical Letters, ;2021, 32(4): 1550-1554. doi: 10.1016/j.cclet.2020.09.052 shu

Phosphate imbalance conducting by BPs-based cancer-targeting phosphate anions carrier induces necrosis

College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

zhanghx@lzu.edu.cn

Received Date: 20 June 2020
Revised Date: 27 September 2020
Accepted Date: 28 September 2020
Available Online: 30 September 2020

Figures(4)

As a vital nutrient closely related to the cancer-cells proliferation, phosphate anions have been paid great attention as a promising anticancer agent. Generally, the transport of phosphate anions depends on a protein transport system which is regulated by ion homeostasis regulations. Herein, we designed a reactive anionic nanocarrier based on black phosphorus nanosheets (BPs) and artesunate (ART), which could enter cells through endocytosis to generate phosphate anions, avoiding the regulation of cell homeostasis. The ionic nanocarrier was coated by polydopamine to defend BPs and ART and functionalized by folate (FA) and hyaluronic acid (HA) for targeting factor. With the anchoring groups FA/HA targeted the carrier into cells, polydopamine coating decomposed to expose ART for further generating reactive oxygen species (ROS) in cancer cell microenvironment, providing oxidation conditions. Next, ROS generated by ART makes BPs decompose to phosphate anions with effectively speed, giving rise to the destruction of ion homeostasis to induce necrosis and inhibit the proliferation for cancer cells. In consequence, this research provides novel idea and direction for the ionic carriers and tumor therapeutics.
- Phosphate anions carrier,
- Black phosphorus nanosheets,
- Artesunate,
- Phosphate imbalance,
- Necrosis
1. [1]
  M.S. Razzaque, Arch. Biochem. Biophys. 561 (2014) 154-158. doi: 10.1016/j.abb.2014.06.031
2. [2]
  M.S. Razzaque, Nat. Rev. Endocrinol. 5 (2009) 611-619. doi: 10.1038/nrendo.2009.196
3. [3]
  Y. Lin, K.E. McKinnon, S.W. Ha, G.R. Beck Jr., Mol. Carcinogen. 54 (2015) 926-934. doi: 10.1002/mc.22153
4. [4]
  P. Liu, H. Cheng, T.M. Roberts, J.J. Zhao, Nat. Rev. Drug Discov. 8 (2009) 627-644. doi: 10.1038/nrd2926
5. [5]
  G.S.D. Marco, M. Hausberg, U. Hillebrand, et al., Am. J. Physiol. Renal Physiol. 294 (2008) F1381-F1387. doi: 10.1152/ajprenal.00003.2008
6. [6]
  L.S. Sapio, L. Sorvillo, M. Illiano, E. Chiosi, A. Spina, S. Naviglio, Molecules 20 (2015) 15910-15928. doi: 10.3390/molecules200915910
7. [7]
  C.F. Dick, A.L.A. Dos-Santos, J.R. Meyer-Fernandes, BBA-Gen. Subjects 1840 (2014) 2123-2127. doi: 10.1016/j.bbagen.2014.03.014
8. [8]
  C. Ma, Y.D. Zhang, Z.J. Jiao, et al., Chin. Chem. Lett. 31 (2019) 1635-1639.
9. [9]
  Y. Zhang, L. Wang, H. Xu, et al., Adv. Funct. Mater. 30 (2020) 1909372. doi: 10.1002/adfm.201909372
10. [10]
  L. Wang, Y. Hu, F. Qi, et al., ACS Appl. Mater. Inter. 12 (2020) 8157-8167. doi: 10.1021/acsami.9b19408
11. [11]
  X.W. Zeng, M.M. Luo, G. Liu, et al., Adv. Sci. 5 (2018) 1800510. doi: 10.1002/advs.201800510
12. [12]
  B.Q. Chen, R.K. Kankala, Y. Zhang, et al., Chem. Eng. J. 390 (2020) 124312. doi: 10.1016/j.cej.2020.124312
13. [13]
  X. Zhang, H.M. Xie, Z.D. Liu, et al., Angew. Chem. Int. Ed. 54 (2015) 3653-3657. doi: 10.1002/anie.201409400
14. [14]
  X.F. Li, R. Grassi, S.C. Li, et al., Nano Lett. 18 (2018) 26-31. doi: 10.1021/acs.nanolett.7b02278
15. [15]
  Q.H. Zhou, Q. Chen, Y.L. Tong, J.L. Wang, Angew. Chem. Int. Ed. 55 (2016) 11437-11441. doi: 10.1002/anie.201605168
16. [16]
  J.O. Island, G.A. Steele, H.S.J. van der Zant, A. Castellanos-Gomez, 2D Mater. 2 (2015) 011002. doi: 10.1088/2053-1583/2/1/011002
17. [17]
  W.H. Zhou, T. Pan, H.D. Cui, et al., Angew. Chem. Int. Ed. 58 (2019) 769-774. doi: 10.1002/anie.201810878
18. [18]
  S.R. Zhang, H. Yuan, Y. Guo, et al., Chem. Commun. 54 (2018) 11717-11720.
19. [19]
  C. Sun, Y. Cao, P. Zhu, B. Zhou, Sci. Rep. -UK 7 (2017) 45665. doi: 10.1038/srep45665
20. [20]
  X. Zhang, Q. Ba, Z.N. Gu, et al., Chem. Eur. J. 21 (2015) 17415-17421. doi: 10.1002/chem.201502543
21. [21]
  J.G. Wang, C.J. Zhang, W.N. Chia, et al., Nat. Commun. 6 (2015) 10111. doi: 10.1038/ncomms10111
22. [22]
  D.D. Bi, L. Zhao, R.Q. Yu, et al., Drug Deliv. 25 (2018) 564-575. doi: 10.1080/10717544.2018.1440447
23. [23]
  N. Li, T.T. Li, C. Hu, et al., ACS Appl. Mater. Inter. 8 (2016) 15013-15023. doi: 10.1021/acsami.5b02037
24. [24]
  Y.L. Liu, K.L. Ai, L.H. Lu, Chem. Rev. 114 (2014) 5057-5115. doi: 10.1021/cr400407a
25. [25]
  X.H. Liang, Y. Sun, L.S. Liu, et al., Chin. Chem. Lett. 23 (2012) 1133-1136. doi: 10.1016/j.cclet.2012.08.006
26. [26]
  X.Q. Quan, L. Kang, X.Z. Yin, et al., Chin. Chem. Lett. 26 (2015) 695-699. doi: 10.1016/j.cclet.2015.04.024
27. [27]
  S. Haller, J. Reber, S. Brandt, et al., Nucl. Med. Biol. 42 (2015) 770-779. doi: 10.1016/j.nucmedbio.2015.06.006
28. [28]
  K. Cohen, R. Emmanuel, E. Kisin-Finfer, D. Shabat, D. Peer, ACS Nano 8 (2014) 2183-2195. doi: 10.1021/nn500205b
29. [29]
  A.K. Yadav, P. Mishra, S. Jain, et al., J. Drug Target. 16 (2008) 464-478. doi: 10.1080/10611860802095494
30. [30]
  M. Culty, H.A. Nguyen, C.B. Underhill, J. Cell Biol. 116 (1992) 1055-1062. doi: 10.1083/jcb.116.4.1055
31. [31]
  B.W. Yang, J.H. Yin, Y. Chen, et al., Adv. Mater. 30 (2018) 1705611. doi: 10.1002/adma.201705611
32. [32]
  Z.B. Sun, H.H. Xie, S.Y. Tang, et al., Angew. Chem. Int. Ed. 54 (2015) 11526-11530. doi: 10.1002/anie.201506154
33. [33]
  Q.S. Zheng, T.R. Lin, H.Y. Wu, et al., Int. J. Pharm. 463 (2014) 22-26. doi: 10.1016/j.ijpharm.2013.12.045
34. [34]
  W. Cheng, J.P. Nie, N.S. Gao, et al., Adv. Funct. Mater. 27 (2017) 1704135. doi: 10.1002/adfm.201704135
35. [35]
  B. Poinard, S. Kamaluddin, A.Q.Q. Tan, et al., ACS Appl. Mater. Inter. 11 (2019) 4777-4789. doi: 10.1021/acsami.8b18107
36. [36]
  W. Tao, X.B. Zhu, X.H. Yu, et al., Adv. Mater. 29 (2017) 1603276. doi: 10.1002/adma.201603276
37. [37]
  L. Wang, Y.J. Hu, Y.W. Hao, et al., J. Control. Release 286 (2018) 74-84. doi: 10.1016/j.jconrel.2018.07.028
38. [38]
  S. Ji, J.Y. Lee, J. Schror, et al., Cancer Lett. 416 (2018) 109-123. doi: 10.1016/j.canlet.2017.12.011
39. [39]
  S. Park, W. Lim, S. You, G. Song, Toxicol. Lett. 313 (2019) 42-49. doi: 10.1016/j.toxlet.2019.05.021
1. [1]
  Yuhao Ma , Yufei Zhou , Mingchuan Yu , Cheng Fang , Shaoxia Yang , Junfeng Niu . Covalently bonded ternary photocatalyst comprising MoSe₂/black phosphorus nanosheet/graphitic carbon nitride for efficient moxifloxacin degradation. Chinese Chemical Letters, 2024, 35(9): 109453-. doi: 10.1016/j.cclet.2023.109453
2. [2]
  Lingna Wang , Chenxin Tian , Ruobin Dai , Zhiwei Wang . Eco-friendly regeneration of end-of-life PVDF membrane with triethyl phosphate: Efficiency and mechanism. Chinese Chemical Letters, 2024, 35(9): 109356-. doi: 10.1016/j.cclet.2023.109356
3. [3]
  Xinxiu Yan , Xizhe Huang , Yangyang Liu , Weishang Jia , Hualin Chen , Qi Yao , Tao Chen . Hyperbranched polyamidoamine protective layer with phosphate and carboxyl groups for dendrite-free Zn metal anodes. Chinese Chemical Letters, 2024, 35(10): 109426-. doi: 10.1016/j.cclet.2023.109426
4. [4]
  Mengjia Luo , Yi Qiu , Zhengyang Zhou . Exploring temperature-driven phase dynamics of phosphate: The periodic to incommensurately modulated long-range ordered phase transition in CsCdPO4. Chinese Journal of Structural Chemistry, 2025, 44(1): 100446-100446. doi: 10.1016/j.cjsc.2024.100446
5. [5]
  Jie Zhou , Chuanxiang Zhang , Changchun Hu , Shuo Li , Yuan Liu , Zhu Chen , Song Li , Hui Chen , Rokayya Sami , Yan Deng . Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg²⁺. Chinese Chemical Letters, 2024, 35(11): 109561-. doi: 10.1016/j.cclet.2024.109561
6. [6]
  Lei Shen , Yang Zhang , Linlin Zhang , Chuanwang Liu , Zhixian Ma , Kangjiang Liang , Chengfeng Xia . Phenylhydrazone anions excitation for the photochemical carbonylation of aryl iodides with aldehydes. Chinese Chemical Letters, 2024, 35(4): 108742-. doi: 10.1016/j.cclet.2023.108742
7. [7]
  Yizhe Chen , Yuzhou Jiao , Liangyu Sun , Cheng Yuan , Qian Shen , Peng Li , Shiming Zhang , Jiujun Zhang . Nonmetallic phosphorus alloying to regulate the oxygen reduction mechanisms of platinum catalyst. Chinese Chemical Letters, 2025, 36(4): 110789-. doi: 10.1016/j.cclet.2024.110789
8. [8]
  Chenghao Ge , Peng Wang , Pei Yuan , Tai Wu , Rongjun Zhao , Rong Huang , Lin Xie , Yong Hua . Tuning hot carrier transfer dynamics by perovskite surface modification. Chinese Chemical Letters, 2024, 35(10): 109352-. doi: 10.1016/j.cclet.2023.109352
9. [9]
  Yinglian LI , Chengcheng ZHANG , Xinyu ZHANG , Xinyi WANG . Spin crossover in [Co(pytpy)₂]²⁺ complexes modified by organosulfonate anions. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1162-1172. doi: 10.11862/CJIC.20240087
10. [10]
  Rong-Nan Yi , Wei-Min He . Electron donor-acceptor complex enabled arylation of dithiocarbamate anions with thianthrenium salts under aqueous micellar conditions. Chinese Chemical Letters, 2024, 35(11): 110194-. doi: 10.1016/j.cclet.2024.110194
11. [11]
  Qiaojia GUO , Junkai CAI , Chunying DUAN . Effects of anions on the structural regulation of Zn-salen-modified metal-organic cage. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2203-2211. doi: 10.11862/CJIC.20240209
12. [12]
  Chunxiu Yu , Zelin Wu , Hongle Shi , Lingyun Gu , Kexin Chen , Chuan-Shu He , Yang Liu , Heng Zhang , Peng Zhou , Zhaokun Xiong , Bo Lai . Insights into the electron transfer mechanisms of peroxydisulfate activation by modified metal-free acetylene black for degradation of sulfisoxazole. Chinese Chemical Letters, 2024, 35(8): 109334-. doi: 10.1016/j.cclet.2023.109334
13. [13]
  Bingke Zhang , Dongbo Wang , Jiamu Cao , Wen He , Gang Liu , Donghao Liu , Chenchen Zhao , Jingwen Pan , Sihang Liu , Weifeng Zhang , Xuan Fang , Liancheng Zhao , Jinzhong Wang . Tuning Stark effect by defect engineering on black titanium dioxide mesoporous spheres for enhanced hydrogen evolution. Chinese Chemical Letters, 2024, 35(11): 110254-. doi: 10.1016/j.cclet.2024.110254
14. [14]
  Yu-Hui Zhang , Ye Tian , Xianliang Sheng , Chen-Shuang Liu , Lu-Qiang Wei , Jie Wang , Yong Chen . Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110193-. doi: 10.1016/j.cclet.2024.110193
15. [15]
  Abiduweili Sikandaier , Yukun Zhu , Dongjiang Yang . In-situ decorated cobalt phosphide cocatalyst on Hittorf's phosphorus triggering efficient photocatalytic hydrogen production. Chinese Journal of Structural Chemistry, 2024, 43(2): 100242-100242. doi: 10.1016/j.cjsc.2024.100242
16. [16]
  Wengao Zeng , Yuchen Dong , Xiaoyuan Ye , Ziying Zhang , Tuo Zhang , Xiangjiu Guan , Liejin Guo . Crystalline carbon nitride with in-plane built-in electric field accelerates carrier separation for excellent photocatalytic hydrogen evolution. Chinese Chemical Letters, 2024, 35(4): 109252-. doi: 10.1016/j.cclet.2023.109252
17. [17]
  Zhiyu Yu , Xiang Luo , Cheng Zhang , Xin Lu , Xiaohui Li , Pan Liao , Zhongqiu Liu , Rong Zhang , Shengtao Wang , Zhiqiang Yu , Guochao Liao . Mitochondria-targeted carrier-free nanoparticles based on dihydroartemisinin against hepatocellular carcinoma. Chinese Chemical Letters, 2024, 35(10): 109519-. doi: 10.1016/j.cclet.2024.109519
18. [18]
  Rongjun Zhao , Tai Wu , Yong Hua , Yude Wang . Improving performance of perovskite solar cells enabled by defects passivation and carrier transport dynamics regulation via organic additive. Chinese Chemical Letters, 2025, 36(2): 109587-. doi: 10.1016/j.cclet.2024.109587
19. [19]
  Liqing Chen , Zheming Zhang , Yanhong Liu , Chenfei Liu , Congcong Xiao , Liming Gong , Mingji Jin , Zhonggao Gao , Wei Huang . Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy. Chinese Chemical Letters, 2025, 36(3): 110228-. doi: 10.1016/j.cclet.2024.110228
20. [20]
  Xiaoyi Meng , Xinyue Sun , Zhaogang Sun , Yue Cheng , Yong Wang , Jun Ye , Yin Xiao , Hongqian Chu . Supramolecular-orchestrated carrier-free chemodynamic synergists with augmented oxidative damage for potentiated cancer therapy. Chinese Chemical Letters, 2025, 36(5): 110765-. doi: 10.1016/j.cclet.2024.110765

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(746)
HTML views(81)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142