Citation: Hangqi Zhu, Bing Zhang, Nali Zhu, Mingchun Li, Qilin Yu. Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions[J]. Chinese Chemical Letters, ;2021, 32(3): 1220-1223. doi: 10.1016/j.cclet.2020.09.003 shu

Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions

Hangqi Zhu ^a ,
Bing Zhang ^{b, c} ,
Nali Zhu ^a ,
Mingchun Li ^{a, *,} ,
Qilin Yu ^{a, *,}

a.
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China

nklimingchun@163.com

yuqilin@mail.nankai.edu.cn

Received Date: 25 May 2020
Revised Date: 31 August 2020
Accepted Date: 3 September 2020
Available Online: 5 September 2020

Figures(5)

In this study, we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide (GO) nanocarriers for efficient impairment of the tumor mitochondria. The two-dimensional GOMNP-MitP nanosheets were synthesized by grafting magnetic γ-Fe₂O₃ to the surface of GO, followed by covalent modification of mitochondrion targeting peptide (MitP). GOMNP-MitP exhibited the high capacity of loading the anticancer drug mitoxantrone (MTX), and preferentially targeted the tumor mitochondria. With the aid of alternating magnetic field (AMF), the MTX-loading GOMNP-MitP released MTX to the mitochondria, severely impairing mitochondrial functions, including attenuation of ATP production, decrease in mitochondrial membrane potential (MMP), and further leading to activation of apoptosis. This study realized high-efficient mitochondrion-targeting drug delivery for anticancer therapy by two-dimensional nanoplatforms.
- Magnetic graphene oxide,
- Nanocarrier,
- Mitochondrion-targeting peptide,
- Mitoxantrone,
- Cancer therapy
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