Citation: Qing-Wen Gui, Fan Teng, Sheng-Neng Ying, Liu Yang, Tao Guo, Jian-Xin Tang, Jin-Yang Chen, Zhong Cao, Wei-Min He. Ultrasound-assisted tandem synthesis of tri- and tetra-substituted pyrrole-2-carbonitriles from alkenes, TMSCN and N, N-disubstituted formamides[J]. Chinese Chemical Letters, ;2020, 31(12): 3241-3244. doi: 10.1016/j.cclet.2020.07.017 shu

Ultrasound-assisted tandem synthesis of tri- and tetra-substituted pyrrole-2-carbonitriles from alkenes, TMSCN and N, N-disubstituted formamides

Qing-Wen Gui ^a ,
Fan Teng ^a ,
Sheng-Neng Ying ^a ,
Liu Yang ^a ,
Tao Guo ^a ,
Jian-Xin Tang ^b ,
Jin-Yang Chen ^c ,
Zhong Cao ^c ,
Wei-Min He ^{c, *,}

a.
College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, China
b.
School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China
c.
Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha 410114, China

weiminhe2016@yeah.net

Received Date: 23 May 2020
Revised Date: 15 June 2020
Accepted Date: 8 July 2020
Available Online: 9 July 2020

Figures(4)

An energy-saving and eco-friendly method for the efficient construction of various tri- and tetra-substituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes, TMSCN and N, N-disubstituted formamides within 40 min under metal-, solvent-free and mild conditions was developed. The dual role of iodine (catalyst and oxidant) notably simplified the reaction conditions and reduced the chemical waste generated.
- Green chemistry,
- Solvent-free,
- Tandem reaction,
- Dual role,
- Ultrasound
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