Citation: Dongjie Fu, Dingchang Liu, Lianbing Zhang, Leming Sun. Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications[J]. Chinese Chemical Letters, ;2020, 31(12): 3195-3199. doi: 10.1016/j.cclet.2020.07.011 shu

Self-assembled fluorescent tripeptide nanoparticles for bioimaging and drug delivery applications

School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, China

lmsun@nwpu.edu.cn

Received Date: 29 May 2020
Revised Date: 6 July 2020
Accepted Date: 6 July 2020
Available Online: 7 July 2020

Figures(4)

Peptide self-assembled nanomaterials have attracted more and more attention due to their wide applications such as drug delivery, cell imaging, and real-time drug monitoring. However, the application of the peptide is still limited by its inherent optical properties. Here we proposed and prepared a series of fluorescent tripeptide nanoparticles (TPNPs) through π-π stacking and zinc coordination. The experimental results show that the nanoparticles (TPNPs1) formed by the self-assembly of the tripeptide tryptophan-tryptophan-tryptophan have the highest fluorescence intensity, uniform and appropriate size, and low cytotoxicity. Furthermore, there was fluorescence resonance between TPNPs1 and doxorubicin, which has been successfully applied for real-time cell imaging and drug release monitoring.
- Self-assembly,
- Tripeptide,
- Fluorescent nanoparticles,
- Bioimaging,
- Doxorubicin,
- Drug delivery
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