Citation: Li Zeng, Zhipeng Su, Xingyi Li, Shuai Shi. Construction of triblock copolymer-gold nanorod composites for fluorescence resonance energy transfer via pH-sensitive allosteric[J]. Chinese Chemical Letters, ;2020, 31(12): 3131-3134. doi: 10.1016/j.cclet.2020.06.039 shu

Construction of triblock copolymer-gold nanorod composites for fluorescence resonance energy transfer via pH-sensitive allosteric

Li Zeng ^a ,
Zhipeng Su ^b ,
Xingyi Li ^a ,
Shuai Shi ^{a, *,}

a.
Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
b.
Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

shuaishi23@163.com

Received Date: 10 May 2020
Revised Date: 27 June 2020
Accepted Date: 29 June 2020
Available Online: 30 July 2020

Figures(4)

To explore the effects of microenvironmental adjustments on fluorescence, a pH-sensitive nano-composite system based on fluorescence resonance energy transfer (FRET) was constructed. The model system included a modified triblock copolymer (polyhistidine-b-polyethylene glycol-b-polycaprolactone) and gold nanoparticles. A near-infrared dye was used as the donor, and spectrally matched gold nanorods, attached after C-terminus modification with α-lipoic acid, were used as the receptor to realize control of the FRET effect over the fluorescence intensity for two polymer configurational changes (i.e., "folded" and "stretched" states) in response to pH. After synthesis and characterization, we investigated the self-assembly behavior of the system. Analysis by quartz crystal microbalance revealed the pH sensitivity of the polymer, which exhibited "folding" and "stretching" states with changes in pH, providing a structural basis for the FRET effect. Fluorescence spectrophotometry investigations also revealed the regulatory impact of the assembled system on fluorescence.
- Fluorescence resonance energy transfer,
- pH response,
- Self-assembled nanoparticle,
- Au nanorod,
- Block copolymer
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沈阳化工大学材料科学与工程学院沈阳 110142