Citation: Yanan Li, Ting Mei, Shupeng Han, Tao Han, Yongbing Sun, Hui Zhang, Feifei An. Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors[J]. Chinese Chemical Letters, ;2020, 31(12): 3027-3040. doi: 10.1016/j.cclet.2020.05.027 shu

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

Yanan Li ^{a, b} ,
Ting Mei ^c ,
Shupeng Han ^c ,
Tao Han ^d ,
Yongbing Sun ^{e, *,} ,
Hui Zhang ^{a, b, *,} ,
Feifei An ^{c, *,}

a.
Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
b.
College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China
c.
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
d.
College of Chemistry and Life Science, Institute of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
e.
Division of Pharmaceutics, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China

20101008@jxutcm.edu.cn

zhang_hui@sxmu.edu.cn

anfeifei@xjtu.edu.cn

Received Date: 18 April 2020
Revised Date: 17 May 2020
Accepted Date: 19 May 2020
Available Online: 23 May 2020

Figures(7)

The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic toxicities. The booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems (nanoDDS) to improve treatment responses and clinical outcomes. In this tutorial review, after introducing the molecular structure and physiological/pathological functions of cathepsin B, the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis, targeted therapy, and synergistic theranostics of malignant tumors are systematically described. Finally, the challenges of enzyme-substrate incompatibility, low diagnostic sensitivity, mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications.
- Tumor microenvironment,
- Cathepsin B,
- Theranostics,
- Precise diagnosis,
- Targeted therapy
1. [1]
  R. Siegel, J. Ma, Z. Zou, A. Jemal, CA Cancer J. Clin. 64(2014) 9-29. doi: 10.3322/caac.21208
2. [2]
  K. Cho, X. Wang, S. Nie, et al., Clin. Cancer Res. 14(2008) 1310-1316. doi: 10.1158/1078-0432.CCR-07-1441
3. [3]
  Y. Xiao, F. An, J. Chen, et al., Small 15(2019) 1903121. doi: 10.1002/smll.201903121
4. [4]
  X. Gong, J. Zhang, S. Jiang, Chem. Commun. 56(2020) 3054-3057. doi: 10.1039/C9CC08768K
5. [5]
  L. Zhong, X. Gong, Soft Matter 15(2019) 9500-9506. doi: 10.1039/C9SM01624D
6. [6]
  Y. Li, Y. Yang, F. An, et al., Nanotechnology 24(2013) 015103. doi: 10.1088/0957-4484/24/1/015103
7. [7]
  Y. Li, Y. Chang, X. Lian, et al., J. Biomed. Nanotechnol. 14(2018) 1515-1542. doi: 10.1166/jbn.2018.2614
8. [8]
  Y. Li, H. Zhang, J. Biomed. Nanotechnol. 15(2019) 1-27. doi: 10.1166/jbn.2019.2670
9. [9]
  Y. Li, H. Zhang, Nanomedicine 14(2019) 1493-1512. doi: 10.2217/nnm-2018-0346
10. [10]
  Y. Li, Q. Dong, T. Mei, et al., Curr. Drug Targets 21(2020) 228-251. doi: 10.2174/1389450120666190807143245
11. [11]
  M. Gu, X. Wang, T.B. Toh, E.K. Chow, Drug Discov. Today 23(2018) 1043-1052. doi: 10.1016/j.drudis.2017.11.009
12. [12]
  S. Mura, J. Nicolas, P. Couvreur, Nat. Mater. 12(2013) 991-1003. doi: 10.1038/nmat3776
13. [13]
  M.R. Junttila, F.J. de Sauvage, Nature 501(2013) 346-354. doi: 10.1038/nature12626
14. [14]
  M. Wang, J. Zhao, L. Zhang, et al., J. Cancer 8(2017) 761-773. doi: 10.7150/jca.17648
15. [15]
  T. Wu, Y. Dai, Cancer Lett. 387(2017) 61-68. doi: 10.1016/j.canlet.2016.01.043
16. [16]
  M. Shahriari, M. Zahiri, K. Abnous, et al., J. Control. Release 308(2019) 172-189. doi: 10.1016/j.jconrel.2019.07.004
17. [17]
  S. Gao, G. Tang, D. Hua, et al., J. Mater. Chem. B 7(2019) 709-729. doi: 10.1039/C8TB02491J
18. [18]
  Y. Tian, M. Lei, L. Yan, F. An, Polym. Chem. 11(2020) 2360-2369. doi: 10.1039/D0PY00004C
19. [19]
  B. Renoux, F. Raes, T. Legigan, et al., Chem. Sci. 8(2017) 3427-3433. doi: 10.1039/C7SC00472A
20. [20]
  H. Chen, Y. Jin, J. Wang, et al., Nanoscale 10(2018) 20946-20962. doi: 10.1039/C8NR07146B
21. [21]
  D. Dheer, J. Nicolas, R. Shankar, Adv. Drug Deliv. Rev.151-152(2019) 130-151. doi: 10.1016/j.addr.2019.01.010
22. [22]
  Y. Sheng, J. Hu, J. Shi, L. Lee, Curr. Med. Chem. 26(2019) 2377-2388. doi: 10.2174/0929867324666170830102409
23. [23]
  T. Hampton, JAMA 319(2018) 2161-2162. doi: 10.1001/jama.2017.12861
24. [24]
  Y. Li, L. Du, C. Wu, et al., Curr. Top. Med. Chem. 19(2019) 74-97. doi: 10.2174/1568026619666190125144621
25. [25]
  C.S. Gondi, J.S. Rao, Expert Opin. Ther. Targets 17(2013) 281-291. doi: 10.1517/14728222.2013.740461
26. [26]
  O.C. Olson, J.A. Joyce, Nat. Rev. Cancer 15(2015) 712-729. doi: 10.1038/nrc4027
27. [27]
  R. Henning, Biochim. Biophys. Acta 401(1975) 307-316. doi: 10.1016/0005-2736(75)90314-4
28. [28]
  R. Xing, A.K. Addington, R.W. Mason, Biochem. J. 332(1998) 499-505. doi: 10.1042/bj3320499
29. [29]
  T. Sun, D. Jiang, L. Zhang, et al., Oncol. Lett. 11(2016) 575-583. doi: 10.3892/ol.2015.3960
30. [30]
  V. Bellat, R. Ting, T.L. Southard, et al., Adv. Funct. Mater. 28(2018) 1803969. doi: 10.1002/adfm.201803969
31. [31]
  H. Kirschke, A.J. Barrett, N.D. Rawlings, Protein Profile 2(1995) 1581-1643.
32. [32]
  I.M. Berquin, L. Cao, D. Fong, B.F. Sloane, Gene 159(1995) 143-149. doi: 10.1016/0378-1119(95)00072-E
33. [33]
  J. Reiser, B. Adair, T. Reinheckel, J. Clin. Invest. 120(2010) 3421-3431. doi: 10.1172/JCI42918
34. [34]
  D. Musil, D. Zucic, D. Turk, et al., EMBO J. 10(1991) 2321-2330. doi: 10.1002/j.1460-2075.1991.tb07771.x
35. [35]
  C. Illy, O. Quraishi, J. Wang, et al., J. Biol. Chem. 272(1997) 1197-1202. doi: 10.1074/jbc.272.2.1197
36. [36]
  J.C. Krupa, S. Hasnain, D.K. Nägler, et al., Biochem. J. 361(2002) 613-619. doi: 10.1042/bj3610613
37. [37]
  J. Schmitz, E. Gilberg, R. Löser, et al., Bioorg. Med. Chem. 27(2019) 1-15. doi: 10.1016/j.bmc.2018.10.017
38. [38]
  A. Mitrović, B. Mirković, I. Sosič, et al., Biol. Chem. 397(2016) 1659-174.
39. [39]
  B. Mirković, B. Markelc, M. Butinar, et al., Oncotarget 6(2015) 19027-19042. doi: 10.18632/oncotarget.3699
40. [40]
  J. Kos, A. Mitrović, B. Mirković, Future Med. Chem. 6(2014) 1355-1371. doi: 10.4155/fmc.14.73
41. [41]
  J.S. Mort, D.J. Buttle, Int. J. Biochem. Cell Biol. 29(1997) 715-720. doi: 10.1016/S1357-2725(96)00152-5
42. [42]
  T. Zhang, Y. Maekawa, J. Hanba, et al., Immunology 100(2000) 13-20. doi: 10.1046/j.1365-2567.2000.00000.x
43. [43]
  H. Büth, P. Luigi Buttigieg, R. Ostafe, et al., Eur. J. Cell Biol. 86(2007) 747-761. doi: 10.1016/j.ejcb.2007.03.009
44. [44]
  H. Büth, B. Wolters, B. Hartwig, et al., Eur. J. Cell Biol. 83(2004) 781-795. doi: 10.1078/0171-9335-00428
45. [45]
  U. Felbor, B. Kessler, W. Mothes, et al., Proc. Natl. Acad. Sci. U. S. A. 99(2002) 7883-7888. doi: 10.1073/pnas.112632299
46. [46]
  O. Mijanovć, A. Branković, A.N. Panin, et al., Cancer Lett. 449(2019) 207-214. doi: 10.1016/j.canlet.2019.02.035
47. [47]
  B. Tong, B. Wan, Z. Wei, et al., Clin. Exp. Immunol. 177(2014) 586-597. doi: 10.1111/cei.12357
48. [48]
  A.A. Aghdassi, D.S. John, M. Sendler, et al., J. Biol. Chem. 293(2018) 1018-1029. doi: 10.1074/jbc.M117.814772
49. [49]
  S. Hartmann, R. Lopez Cruz, S. Alameh, et al., ACS Infect. Dis. 4(2018) 1235-1245. doi: 10.1021/acsinfecdis.8b00053
50. [50]
  H. Nakanishi, Neural Regeneration Res. 15(2020) 25-29. doi: 10.4103/1673-5374.264444
51. [51]
  A. Baici, K. Müntener, A. Willimann, R. Zwicky, Biol. Chem. 387(2006) 1017-1021.
52. [52]
  J.R. Pungercar, D. Caglic, M. Sajid, et al., FEBS J. 276(2009) 660-668. doi: 10.1111/j.1742-4658.2008.06815.x
53. [53]
  B. Breznik, A. Mitrović, T.L. T, J. Kos, Biochimie 166(2019) 233-250. doi: 10.1016/j.biochi.2019.05.002
54. [54]
  O. Meurette, P. Mehlen, Cancer Cell 34(2018) 536-548. doi: 10.1016/j.ccell.2018.07.009
55. [55]
  M.M. Mohamed, B.F. Sloane, Nat. Rev. Cancer 6(2006) 764-775. doi: 10.1038/nrc1949
56. [56]
  E. Guerra, A. Cimadamore, P. Simeone, et al., BMC Cancer 16(2016) 649. doi: 10.1186/s12885-016-2713-3
57. [57]
  G. Kostoulas, A. Lang, H. Nagase, A. Baici, FEBS Lett. 455(1999) 286-290. doi: 10.1016/S0014-5793(99)00897-2
58. [58]
  J.E. Koblinski, M. Ahram, B.F. Sloane, Clin. Chim. Acta 291(2000) 113-135. doi: 10.1016/S0009-8981(99)00224-7
59. [59]
  O. Vasiljeva, B. Turk, Biochimie 90(2008) 380-386. doi: 10.1016/j.biochi.2007.10.004
60. [60]
  J. Mu, J. Lin, P. Huang, X. Chen, Chem. Soc. Rev. 47(2018) 5554-5573. doi: 10.1039/C7CS00663B
61. [61]
  E. Li, Y. Yang, G. Hao, et al., Nanotheranostics 2(2018) 233-242. doi: 10.7150/ntno.25565
62. [62]
  H.J. Cho, S. Lee, S.J. Park, et al., Colloid Surf. B:Biointerfaces 179(2019) 9-16. doi: 10.1016/j.colsurfb.2019.03.047
63. [63]
  J. Ding, J. Chen, L. Gao, et al., Nano Today 29(2019) 100800. doi: 10.1016/j.nantod.2019.100800
64. [64]
  T.M. Allen, P.R. Cullis, Adv. Drug Deliv. Rev. 65(2013) 36-48. doi: 10.1016/j.addr.2012.09.037
65. [65]
  K. Zhao, D. Li, C. Shi, et al., Curr. Drug Deliv. 13(2016) 494-499. doi: 10.2174/156720181304160521004609
66. [66]
  I.A. Isoglu, Y. Ozsoy, S.D. Isoglu, Curr. Top. Med. Chem. 17(2017) 1469-1489. doi: 10.2174/1568026616666161222110600
67. [67]
  A.S. Chauhan, Molecules 23(2018) 938. doi: 10.3390/molecules23040938
68. [68]
  Y. Jiang, S. Huo, J. Hardie, et al., Expert Opin. Drug Deliv. 13(2016) 547-559. doi: 10.1517/17425247.2016.1134486
69. [69]
  X. Ma, L. Gao, Y. Tang, M. Peng, Part. Part. Syst. Charact. 35(2017) 1700326.
70. [70]
  C.T. Matea, T. Mocan, F. Tabaran, et al., Int. J. Nanomed. 12(2017) 5421-5431. doi: 10.2147/IJN.S138624
71. [71]
  S. Sengupta, R. Sasisekharan, Br. J. Cancer 96(2007) 1315-1319. doi: 10.1038/sj.bjc.6603707
72. [72]
  X. Zhou, Y. Hao, L. Yuan, et al., Chin. Chem. Lett. 29(2018) 1713-1724. doi: 10.1016/j.cclet.2018.10.037
73. [73]
  P. Li, Y. Chen, Y. Liu, Chin. Chem. Lett. 30(2019) 1190-1197. doi: 10.1016/j.cclet.2019.03.035
74. [74]
  L. Guo, H. Chen, N. He, Y. Deng, Chin. Chem. Lett. 29(2018) 1829-1833. doi: 10.1016/j.cclet.2018.10.038
75. [75]
  K. Wieland, G. Ramer, V.U. Weiss, et al., Nano Res. 12(2019) 197-203. doi: 10.1007/s12274-018-2202-x
76. [76]
  X. Fu, J. Cai, X. Zhang, et al., Adv. Drug Deliv. Rev. 132(2018) 169-187. doi: 10.1016/j.addr.2018.07.006
77. [77]
  M. Ranjbar, A. Pardakhty, A. Amanatfard, A. Asadipour, Drug Des. Devil. Ther. 12(2018) 2635-2643. doi: 10.2147/DDDT.S173324
78. [78]
  M.T. Alula, P. Lemmens, L. Bo, et al., Anal. Chim. Acta 1073(2019) 62-71. doi: 10.1016/j.aca.2019.04.061
79. [79]
  H. Peng, Q. Huang, T. Wu, et al., Curr. Drug Deliv. 15(2018) 278-285. doi: 10.2174/1567201814666170224144217
80. [80]
  W. Yu, T. Sun, C. Qi, et al., ACS Appl. Mater. Interfaces 9(2017) 3306-3317. doi: 10.1021/acsami.6b12325
81. [81]
  T. Sun, Y. Zhu, C. Qi, et al., J. Mater. Chem., B 4(2016) 3257-3268. doi: 10.1039/C5TB02632F
82. [82]
  H. Liu, J. Mei, Y. Xu, et al., Int. J. Nanomed. 14(2019) 8739-8751. doi: 10.2147/IJN.S224044
83. [83]
  E.S. Dolinina, E.V. Parfenyuk, Curr. Drug Deliv. 14(2017) 734-740.
84. [84]
  R. Fang, C. Hu, B.T. Luk, et al., Nano Lett. 14(2014) 2181-2188. doi: 10.1021/nl500618u
85. [85]
  L.C. Glangchai, M. Caldorera-Moore, L. Shi, K. Roy, J. Control. Release 125(2008) 263-272. doi: 10.1016/j.jconrel.2007.10.021
86. [86]
  V. Bellat, H.H. Lee, L. Vahdat, B. Law, Biomacromolecules 17(2016) 2040-2049. doi: 10.1021/acs.biomac.6b00227
87. [87]
  R. Löser, J. Pietzsch, Front. Chem. 3(2015) 37.
88. [88]
  E. Gounaris, C.H. Tung, C. Restaino, et al., PLoS One 3(2008) e2916. doi: 10.1371/journal.pone.0002916
89. [89]
  V. Lyo, F. Cattaruzza, T.N. Kim, et al., Am. J. Physiol. Gastrointest. Liver Physiol. 303(2012) G894-G903. doi: 10.1152/ajpgi.00073.2012
90. [90]
  D.V. Hingorani, L.A. Montano, E.A. Randtke, et al., Contrast Media Mol. Imaging 11(2016) 130-138. doi: 10.1002/cmmi.1672
91. [91]
  M.E. Roth-Konforti, C.R. Bauer, D. Shabat, Angew. Chem. Int. Ed. 56(2017) 15633-15638. doi: 10.1002/anie.201709347
92. [92]
  L.S. Ryan, A.R. Lippert, Angew. Chem. Int. Ed. 57(2018) 622-624. doi: 10.1002/anie.201711228
93. [93]
  Q. Wang, L. Yu, R.C.H. Wong, P.C. Lo, Eur. J. Med. Chem. 179(2019) 828-836. doi: 10.1016/j.ejmech.2019.06.082
94. [94]
  H. Shen, J. Liu, J. Lei, H. Ju, Chem. Commun. 54(2018) 9155-9158. doi: 10.1039/C8CC04621B
95. [95]
  X. Gao, J. Li, M. Luan, et al., Biosens. Bioelectron. 147(2020) 111755. doi: 10.1016/j.bios.2019.111755
96. [96]
  R. Zhang, J. Yang, D.C. Radford, et al., Macromol. Biosci. 17(2017) 1600125. doi: 10.1002/mabi.201600125
97. [97]
  E. Kisin-Finfer, S. Ferber, R. Blau, et al., Bioorg. Med. Chem. Lett. 24(2014) 2453-2458. doi: 10.1016/j.bmcl.2014.04.022
98. [98]
  H. Li, C.H. Lee, I. Shin, Org. Lett. 21(2019) 4628-4631. doi: 10.1021/acs.orglett.9b01530
99. [99]
  G. Saranya, M.M. Joseph, V. Karunakaran, et al., ACS Appl. Mater. Interfaces 10(2018) 38807-38818. doi: 10.1021/acsami.8b15583
100. [100]
  L. Sun, X. Li, X. Wei, et al., ACS Appl. Mater. Interfaces 8(2016) 10499-10512. doi: 10.1021/acsami.6b00980
101. [101]
  Y. Wang, Y. Dai, Q. Luo, et al., J. Biomed. Nanotechnol. 15(2019) 1384-1400. doi: 10.1166/jbn.2019.2759
102. [102]
  S. Tran, P.J. DeGiovanni, B. Piel, P. Rai, Clin. Transl. Med. 6(2017) 44.
103. [103]
  Y. Cheng, G. Luo, J. Zhu, et al., ACS Appl. Mater. Interfaces 7(2015) 9078-9087. doi: 10.1021/acsami.5b00752
104. [104]
  Z. Wang, R. Zhang, T. Zhang, et al., ACS Appl. Mater. Interfaces 10(2018) 41056-41069. doi: 10.1021/acsami.8b14001
105. [105]
  S.P. Tarassoli, A.M. de Pinillos Bayona, H. Pye, et al., Nanotechnology 28(2017) 055101. doi: 10.1088/1361-6528/28/5/055101
106. [106]
  Y. Li, Q. Dong, Y. Cui, Cancer Biol. Med. 16(2019) 415-434.
107. [107]
  C. Zhang, L. Liu, W. Qiu, et al., Small 14(2018) 1703321. doi: 10.1002/smll.201703321
108. [108]
  F. Wang, M. Wang, L. Zhao, Q. Li, Mater. Express 9(2019) 1076-1081. doi: 10.1166/mex.2019.1602
109. [109]
  X. Duan, X. Yang, C. Dai, et al., Mater. Express 9(2019) 757-763. doi: 10.1166/mex.2019.1552
110. [110]
  Y. Luo, X. Sun, L. Huang, et al., ACS Appl. Mater. Interfaces 11(2019) 29490-29497. doi: 10.1021/acsami.9b07390
111. [111]
  Z. Guo, L. Shi, H. Feng, et al., Chin. Chem. Lett. 31(2020), doi: http://dx.doi.org/10.1016/j.cclet.2020.03.066.
112. [112]
  L. Bildstein, C. Dubernet, P. Couvreur, Adv. Drug Deliv. Rev. 63(2011) 3-23. doi: 10.1016/j.addr.2010.12.005
113. [113]
  V. Bala, S. Rao, B.J. Boyd, C.A. Prestidge, J. Control. Release 172(2013) 48-61. doi: 10.1016/j.jconrel.2013.07.022
114. [114]
  Q. Guo, H. Wang, Y. Zhao, et al., Polym. Chem. 4(2013) 4584-4587. doi: 10.1039/c3py00742a
115. [115]
  Y. Chen, W. Zhang, Y. Huang, et al., Int. J. Pharm. 488(2015) 44-58. doi: 10.1016/j.ijpharm.2015.04.048
116. [116]
  X. Duan, J. Xiao, Q. Yin, et al., ACS Nano 7(2013) 5858-5869. doi: 10.1021/nn4010796
117. [117]
  L. Gao, Z. Yu, D. Meng, et al., Protein Pept. Lett. 22(2015) 762-766. doi: 10.2174/0929866522666150622101944
118. [118]
  Y. Dai, X. Ma, Y. Zhang, et al., Biomater. Sci. 6(2018) 2976-2986. doi: 10.1039/C8BM00946E
119. [119]
  C. Zhang, D. Pan, J. Li, et al., Acta Biomater. 55(2017) 153-162. doi: 10.1016/j.actbio.2017.02.047
120. [120]
  Y. Zhong, L. Shao, Y. Li, Int. J. Oncol. 42(2013) 373-383. doi: 10.3892/ijo.2012.1754
121. [121]
  S.J. Lee, Y.I. Jeong, H.K. Park, et al., Int. J. Nanomed. 10(2015) 5489-5503.
122. [122]
  Z. Peng, J. Kopecek, J. Am. Chem. Soc. 137(2015) 67269-6729.
123. [123]
  X. Wei, Q. Luo, L. Sun, et al., ACS Appl. Mater. Interfaces 8(2016) 11765-11778. doi: 10.1021/acsami.6b02006
124. [124]
  Y. Ou, K. Chen, H. Cai, et al., Biomater. Sci. 6(2018) 1177-1188. doi: 10.1039/C8BM00095F
125. [125]
  Y. Liang, S. Li, X. Wang, et al., J. Control. Release 275(2018) 129-141. doi: 10.1016/j.jconrel.2018.01.033
126. [126]
  L. Qiu, L. Zhao, C. Xing, Y. Zhan, Chin. Chem. Lett. 29(2018) 301-304. doi: 10.1016/j.cclet.2017.09.048
127. [127]
  J. Li, F. Liu, Q. Shao, et al., Adv. Health. Mater. 3(2014) 1230-1239. doi: 10.1002/adhm.201300613
128. [128]
  H. Zhang, X. Zhao, L. Chen, et al., Anal. Chem. 92(2020) 1179-1188. doi: 10.1021/acs.analchem.9b04318
129. [129]
  H. Han, Q. Jin, Y. Wang, et al., Chem. Commun. 51(2015) 17435-17438. doi: 10.1039/C5CC06654A
130. [130]
  H. Han, J. Wang, T. Chen, et al., J. Colloid Interface Sci. 507(2017) 217-224. doi: 10.1016/j.jcis.2017.07.047
131. [131]
  M.L. Yap, J.D. McFadyen, X. Wang, et al., Theranostics 9(2019) 1154-1169. doi: 10.7150/thno.29146
132. [132]
  L. Huang, Y. Luo, X. Sun, et al., Biosens. Bioelectron. 92(2017) 724-732. doi: 10.1016/j.bios.2016.10.004
133. [133]
  Y. Yang, Q. Chen, S. Li, et al., J. Biomed. Nanotechnol. 14(2018) 1396-1408. doi: 10.1166/jbn.2018.2592
134. [134]
  X. Li, Y. Zhang, Z. Ma, et al., Chin. Chem. Lett. 30(2019) 489-493. doi: 10.1016/j.cclet.2018.03.019
135. [135]
  J. Tian, L. Ding, Q. Wang, et al., Anal. Chem. 87(2015) 3841-3848. doi: 10.1021/acs.analchem.5b00429
136. [136]
  Y.I. Jeong, S.Y. Yoo, J. Heo, D.H. Kang, ACS Omega 4(2019) 18593-18599. doi: 10.1021/acsomega.9b02386
137. [137]
  J. Kim, C.H. Tung, Y. Choi, Chem. Commun. 50(2014) 10600-10603. doi: 10.1039/C4CC04166F
138. [138]
  X. Chen, D. Lee, S. Yu, et al., Biomaterials 122(2017) 130-140. doi: 10.1016/j.biomaterials.2017.01.020
139. [139]
  J. Liu, L. Zhang, J. Lei, et al., ACS Appl. Mater. Interfaces 9(2017) 2150-2158. doi: 10.1021/acsami.6b14446
140. [140]
  Y. Yang, J. Aw, K. Chen, et al., Chem. Asian J. 6(2011) 1381-1389. doi: 10.1002/asia.201000905
141. [141]
  G. Mikhaylov, D. Klimpel, N. Schaschke, et al., Angew. Chem. Int. Ed. 53(2014) 10077-10081. doi: 10.1002/anie.201402305
142. [142]
  F. An, Z. Yang, M. Zheng, et al., J. Nanobiotechnol. 18(2020) 49. doi: 10.1186/s12951-020-00603-8
143. [143]
  J. Li, Z. Tian, X. Ge, et al., Eur. J. Med. Chem. 163(2019) 830-839. doi: 10.1016/j.ejmech.2018.12.021
144. [144]
  S. Ferber, H. Baabur-Cohen, R. Blau, et al., Cancer Lett. 352(2014) 81-89. doi: 10.1016/j.canlet.2014.02.022
145. [145]
  S.M. Shon, Y. Choi, J.Y. Kim, et al., Arterioscler. Thromb. 33(2013) 1360-1365. doi: 10.1161/ATVBAHA.113.301290
146. [146]
  B. Wang, P. Lv, H. Cai, et al., J. Biomed. Nanotechnol. 15(2019) 1897-1908. doi: 10.1166/jbn.2019.2833
147. [147]
  H. Gao, H. Feng, Y. Bai, et al., J. Biomed. Nanotechnol. 15(2019) 1764-1770. doi: 10.1166/jbn.2019.2805
148. [148]
  S.T. Gunawan, K. Liang, G.K. Such, et al., Small 10(2014) 4080-4086.
149. [149]
  M. Fathi, A. Safary, J. Barar, Bioimpacts 10(2020) 1-4.
150. [150]
  C. Hu, A. Qian, Q. Wang, et al., Eur. J. Pharm. Biopharm. 109(2016) 206-213. doi: 10.1016/j.ejpb.2016.10.018
151. [151]
  H. Jia, Y. Zhu, Q. Duan, et al., J. Control. Release 311-312(2019) 301-318. doi: 10.1016/j.jconrel.2019.08.022
1. [1]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
2. [2]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
3. [3]
  Li Fu , Ziye Su , Shuyang Wu , Yanfen Cheng , Chuan Hu , Jinming Zhang . Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chemical Letters, 2025, 36(5): 110227-. doi: 10.1016/j.cclet.2024.110227
4. [4]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
5. [5]
  Yunkang Tong , Haiqiao Huang , Haolan Li , Mingle Li , Wen Sun , Jianjun Du , Jiangli Fan , Lei Wang , Bin Liu , Xiaoqiang Chen , Xiaojun Peng . Cooperative bond scission by HRP/H₂O₂ for targeted prodrug activation. Chinese Chemical Letters, 2024, 35(12): 109663-. doi: 10.1016/j.cclet.2024.109663
6. [6]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
7. [7]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
8. [8]
  Si Ha , Jiacheng Zhu , Hua Xiang , Guoshun Luo . Hydrophobic tag tethering degrader as a promising paradigm of protein degradation: Past, present and future perspectives. Chinese Chemical Letters, 2024, 35(8): 109192-. doi: 10.1016/j.cclet.2023.109192
9. [9]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
10. [10]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
11. [11]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
12. [12]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
13. [13]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
14. [14]
  Shangqian Zhang , Jiaxuan Li , Xuan Hu , Zelong Chen , Junliang Dong , Chenhao Hu , Shuang Chao , Yinghua Lv , Yuxin Pei , Zhichao Pei . H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chinese Chemical Letters, 2025, 36(1): 110314-. doi: 10.1016/j.cclet.2024.110314
15. [15]
  Jialiang XU , Jiabin CUI . Recent biological applications of corroles: From diagnosis to therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2303-2317. doi: 10.11862/CJIC.20240245
16. [16]
  Zhihui Zhang , Ru Sun , Chong Bian , Hongbo Wang , Zhen Zhao , Panpan Lv , Jianzhong Lu , Haixin Zhang , Hulie Zeng , Yuanyuan Chen , Zhijuan Cao . A dual-protease-triggered chemiluminescent probe for precise tumor imaging. Chinese Chemical Letters, 2025, 36(2): 109784-. doi: 10.1016/j.cclet.2024.109784
17. [17]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
18. [18]
  Yang Liu , Minglu Li , Jianxun Ding , Xuesi Chen . Glycoengineering-assistant biomineralization for tumor blockade therapy. Chinese Chemical Letters, 2025, 36(5): 110146-. doi: 10.1016/j.cclet.2024.110146
19. [19]
  Chao Zhang , Ai-Feng Liu , Shihui Li , Fang-Yuan Chen , Jun-Tao Zhang , Fang-Xing Zeng , Hui-Chuan Feng , Ping Wang , Wen-Chao Geng , Chuan-Rui Ma , Dong-Sheng Guo . A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chinese Chemical Letters, 2025, 36(1): 109752-. doi: 10.1016/j.cclet.2024.109752
20. [20]
  Xinyu Tian , Jiaxiang Guo , Zeyi Li , Shihou Sheng , Tianyu Zhang , Xianfei Li , Chuandong Dou . Control over electronic structures of organic diradicaloids via precise B/O-heterocycle fusion. Chinese Chemical Letters, 2025, 36(1): 110174-. doi: 10.1016/j.cclet.2024.110174

Get Citation

PDF

XML

Metrics

PDF Downloads(17)
Abstract views(1348)
HTML views(216)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142