Citation: Yanan Li, Ting Mei, Shupeng Han, Tao Han, Yongbing Sun, Hui Zhang, Feifei An. Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors[J]. Chinese Chemical Letters, ;2020, 31(12): 3027-3040. doi: 10.1016/j.cclet.2020.05.027 shu

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

Yanan Li ^{a, b} ,
Ting Mei ^c ,
Shupeng Han ^c ,
Tao Han ^d ,
Yongbing Sun ^{e, *,} ,
Hui Zhang ^{a, b, *,} ,
Feifei An ^{c, *,}

a.
Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
b.
College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China
c.
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
d.
College of Chemistry and Life Science, Institute of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
e.
Division of Pharmaceutics, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China

20101008@jxutcm.edu.cn

zhang_hui@sxmu.edu.cn

anfeifei@xjtu.edu.cn

Received Date: 18 April 2020
Revised Date: 17 May 2020
Accepted Date: 19 May 2020
Available Online: 23 May 2020

Figures(7)

The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic toxicities. The booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems (nanoDDS) to improve treatment responses and clinical outcomes. In this tutorial review, after introducing the molecular structure and physiological/pathological functions of cathepsin B, the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis, targeted therapy, and synergistic theranostics of malignant tumors are systematically described. Finally, the challenges of enzyme-substrate incompatibility, low diagnostic sensitivity, mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications.
- Tumor microenvironment,
- Cathepsin B,
- Theranostics,
- Precise diagnosis,
- Targeted therapy
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