Citation: Yixin Zhang, Shunjie Ding, Junhua Li, Xinyu Peng, Jing Li, Jing Chang, Wenxia Gao, Bin He. In vivo formation of Cu(DDC)₂ complex induced by nanomedicine for mesothelioma chemotherapy[J]. Chinese Chemical Letters, ;2020, 31(12): 3168-3172. doi: 10.1016/j.cclet.2020.04.051 shu

In vivo formation of Cu(DDC)₂ complex induced by nanomedicine for mesothelioma chemotherapy

Yixin Zhang ^a ,
Shunjie Ding ^b ,
Junhua Li ^a ,
Xinyu Peng ^a ,
Jing Li ^a ,
Jing Chang ^c ,
Wenxia Gao ^{d, *,} ,
Bin He ^{a, *,}

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
Army Logistics University of PLA, Chongqing 401331, China
c.
College of Marine Life Science, Ocean University of China, Qingdao 266003, China
d.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China

wenxiag@wzu.edu.cn

bhe@scu.edu.cn

Received Date: 24 March 2020
Revised Date: 24 April 2020
Accepted Date: 27 April 2020
Available Online: 7 May 2020

Figures(5)

The copper(II) diethyldithiocarbamate (Cu(DDC)₂) complex exhibited excellent inhibition to cancer cells. The usual administration is intravenous injection for disulfram and oral for copper. A new strategy was reported to improve the administration efficiency of the Cu(DDC)₂ drug. Poly(lactide-co-glycolide) (PLGA) nanoparticles were used to trap disulfram and copper gluconate separately, the two types of drug loaded nanoparticles were injected in mesothelioma-bearing nude mice via intraperitoneal injection. The in vivo formation of Cu(DDC)₂ complex was induced by disulfiram and Cu²⁺ released from PLGA nanoparticles. This strategy avoided many obstacles in the use of Cu(DDC)₂ complex as chemotherapeutic and exhibited excellent anticancer activity to mesothelioma.
- Mesothelioma,
- Nanoparticles,
- In vivo formation,
- PLGA,
- Cu(DDC)₂ complex
1. [1]
  B.M. Robinson, Ann. Cardiothorac. Surg. 1(2012) 491-496. doi: 10.3978/j.issn.2225-319X.2012.11.04
2. [2]
  F. Sonvico, S. Barbieri, P. Colombo, et al., J. Thorac. Dis. 10(2018) S194-S206. doi: 10.21037/jtd.2017.10.12
3. [3]
  R.L. Attanoos, A.R. Gibbs, Histopathology 30(1997) 403-418. doi: 10.1046/j.1365-2559.1997.5460776.x
4. [4]
  K. Donaldson, F.A. Murphy, R. Duffin, C.A. Poland, Part. Fibre Toxicol. 7(2010) 5. doi: 10.1186/1743-8977-7-5
5. [5]
  H.L. Kindler, N. Ismaila, S.G. Armato, R. Bueno, R. Hassan, J. Clin. Oncol. 36(2018) 1343-1373. doi: 10.1200/JCO.2017.76.6394
6. [6]
  T.A. Yap, J.G. Aerts, S. Popat, D.A. Fennell, Nat. Rev. Cancer 17(2017) 475-488. doi: 10.1038/nrc.2017.42
7. [7]
  Z. Yu, Q. Chen, Y. Yang, et al., Chem. Commun. 54(2018) 5369-5372. doi: 10.1039/C8CC02791A
8. [8]
  Y. Yu, Q. Xu, S. He, et al., Coord. Chem. Rev. 387(2019) 154-179. doi: 10.1016/j.ccr.2019.01.020
9. [9]
  Z. Chen, C. Wu, Z. Zhang, et al., Chin. Chem. Lett. 29(2018) 1601-1608. doi: 10.1016/j.cclet.2018.08.007
10. [10]
  Y. Sun, W. Ma, Y. Yang, et al., Asian J. Pharm. Sci. 14(2019) 581-594. doi: 10.1016/j.ajps.2019.04.005
11. [11]
  P. Liu, S. Brown, T. Goktug, P. Channathodiyil, W. Wang, Br. J. Cancer 107(2012) 1488-1497. doi: 10.1038/bjc.2012.442
12. [12]
  W. Song, Z. Tang, T. Lei, et al., Nanomedicine 12(2015) 377-386.
13. [13]
  H. Nechushtan, Y. Hamamreh, S. Nidal, et al., Oncologist 20(2015) 366-367. doi: 10.1634/theoncologist.2014-0424
14. [14]
  D.J. Lewis, P. Deshmukh, A.A. Tedstone, F. Tuna, P. O'Brien, Chem. Commun. 50(2014) 13334-13337. doi: 10.1039/C4CC04767B
15. [15]
  I.G. Konkina, S.P. Ivanov, O.A. Knyazeva, V.A. Davydova, Y.I. Murinov, Pharm. Chem. J. 36(2002) 18-21. doi: 10.1023/A:1015792623287
16. [16]
  B. Johansson, Acta Psychiatr. Scand. Suppl. 86(2010) 15-26. doi: 10.1111/j.1600-0447.1992.tb03310.x
17. [17]
  P. Liu, W. Zhipeng, B. Sarah, et al., Oncotarget 5(2014) 7471-7485. doi: 10.18632/oncotarget.2166
18. [18]
  X. Duan, J. Xiao, Q. Yin, et al., ACS Nano 7(2013) 5858-5869. doi: 10.1021/nn4010796
19. [19]
  X. Peng, Q. Pan, B. Zhang, et al., Biomacromolecules 20(2019) 2372-2383. doi: 10.1021/acs.biomac.9b00367
20. [20]
  Q. Pan, B. Zhang, X. Peng, et al., Chem. Commun. 55(2019) 13896-13899. doi: 10.1039/C9CC05438C
21. [21]
  F. Yasmin, X. Chen, B.F. Eames, J. Funct. Biomater. 10(2019) 42. doi: 10.3390/jfb10030042
22. [22]
  X. Zhou, Y. Hao, L. Yuan, S. Pradhan, K. Shrestha, Chin. Chem. Lett. 29(2018) 1713-1724.
23. [23]
  Q. Liang, L. Zhao, C. Xing, Z. Yong, Chin. Chem. Lett. 29(2018) 97-100.
24. [24]
  S. Bee, Z.A.A. Hamid, M. Mariatti, B.H. Yahaya, K. Lim, J. Macromol. Sci. Polym. Rev. 58(2018) 495-536.
25. [25]
  D. Bikiaris, E. Koutris, E. Karavas, Recent Pat. Drug Deliv. Formul. 1(2007) 201-213. doi: 10.2174/187221107782331629
26. [26]
  Y. Wang, X. Wang, J. Zhang, L. Wang, C. Gong, Chin. Chem. Lett. 30(2019) 885-888.
27. [27]
  Y. Sun, A. Zhan, S. Zhou, et al., Chin. Chem. Lett. 30(2019) 1435-1439. doi: 10.1016/j.cclet.2019.05.001
28. [28]
  M. Deng, Z. Jiang, Y. Li, Y. Zhou, B. Xu, Oncotarget 7(2016) 82200-82212.
1. [1]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
2. [2]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619
3. [3]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
4. [4]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
5. [5]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
6. [6]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
7. [7]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
8. [8]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
9. [9]
  Fereshte Hassanzadeh-Afruzi , Mina Azizi , Iman Zare , Ehsan Nazarzadeh Zare , Anwarul Hasan , Siavash Iravani , Pooyan Makvandi , Yi Xu . Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing. Chinese Chemical Letters, 2024, 35(11): 109564-. doi: 10.1016/j.cclet.2024.109564
10. [10]
  Shenglan Zhou , Haijian Li , Hongyi Gao , Ang Li , Tian Li , Shanshan Cheng , Jingjing Wang , Jitti Kasemchainan , Jianhua Yi , Fengqi Zhao , Wengang Qu . Recent advances in metal-loaded MOFs photocatalysts: From single atom, cluster to nanoparticle. Chinese Chemical Letters, 2025, 36(1): 110142-. doi: 10.1016/j.cclet.2024.110142
11. [11]
  Xiangyuan Zhao , Jinjin Wang , Jinzhao Kang , Xiaomei Wang , Hong Yu , Cheng-Feng Du . Ni nanoparticles anchoring on vacuum treated Mo2TiC2Tx MXene for enhanced hydrogen evolution activity. Chinese Journal of Structural Chemistry, 2023, 42(10): 100159-100159. doi: 10.1016/j.cjsc.2023.100159
12. [12]
  Shiqi Peng , Yongfang Rao , Tan Li , Yufei Zhang , Jun-ji Cao , Shuncheng Lee , Yu Huang . Regulating the electronic structure of Ir single atoms by ZrO₂ nanoparticles for enhanced catalytic oxidation of formaldehyde at room temperature. Chinese Chemical Letters, 2024, 35(7): 109219-. doi: 10.1016/j.cclet.2023.109219
13. [13]
  Chang LIU , Chao ZHANG , Tongbu LU . Small-size Au nanoparticles anchored on pyrenyl-graphdiyne for N₂ electroreduction. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 174-182. doi: 10.11862/CJIC.20240305
14. [14]
  Guoju Guo , Xufeng Li , Jie Ma , Yongjia Shi , Jian Lv , Daoshan Yang . Photocatalyst/metal-free sequential C–N/C–S bond formation: Synthesis of S-arylisothioureas via photoinduced EDA complex activation. Chinese Chemical Letters, 2024, 35(11): 110024-. doi: 10.1016/j.cclet.2024.110024
15. [15]
  Ke Wang , Jia Wu , Shuyi Zheng , Shibin Yin . NiCo Alloy Nanoparticles Anchored on Mesoporous Mo2N Nanosheets as Efficient Catalysts for 5-Hydroxymethylfurfural Electrooxidation and Hydrogen Generation. Chinese Journal of Structural Chemistry, 2023, 42(10): 100104-100104. doi: 10.1016/j.cjsc.2023.100104
16. [16]
  Xingxing Jiang , Yuxin Zhao , Yan Kong , Jianju Sun , Shangzhao Feng , Xin Lu , Qi Hu , Hengpan Yang , Chuanxin He . Support effect and confinement effect of porous carbon loaded tin dioxide nanoparticles in high-performance CO₂ electroreduction towards formate. Chinese Chemical Letters, 2025, 36(1): 109555-. doi: 10.1016/j.cclet.2024.109555
17. [17]
  Yubang Li , Xixi Hu , Daiqian Xie . The microscopic formation mechanism of O + H2 products from photodissociation of H2O. Chinese Journal of Structural Chemistry, 2024, 43(5): 100274-100274. doi: 10.1016/j.cjsc.2024.100274
18. [18]
  Gengchen Guo , Tianyu Zhao , Ruichang Sun , Mingzhe Song , Hongyu Liu , Sen Wang , Jingwen Li , Jingbin Zeng . Au-Fe₃O₄ dumbbell-like nanoparticles based lateral flow immunoassay for colorimetric and photothermal dual-mode detection of SARS-CoV-2 spike protein. Chinese Chemical Letters, 2024, 35(6): 109198-. doi: 10.1016/j.cclet.2023.109198
19. [19]
  Bharathi Natarajan , Palanisamy Kannan , Longhua Guo . Metallic nanoparticles for visual sensing: Design, mechanism, and application. Chinese Journal of Structural Chemistry, 2024, 43(9): 100349-100349. doi: 10.1016/j.cjsc.2024.100349
20. [20]
  Xiangjun Zhang , Xiaodi Yang , Yan Wang , Zhongping Xu , Sisi Yi , Tao Guo , Yue Liao , Xiyu Tang , Jianxiang Zhang , Ruibing Wang . A supramolecular nanoprodrug for prevention of gallstone formation. Chinese Chemical Letters, 2025, 36(2): 109854-. doi: 10.1016/j.cclet.2024.109854

Get Citation

PDF

XML

Metrics

PDF Downloads(7)
Abstract views(1209)
HTML views(209)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy

Metrics

通讯作者: 陈斌, bchen63@163.com

In vivo formation of Cu(DDC)₂ complex induced by nanomedicine for mesothelioma chemotherapy