Citation: Yang Liu, Di Li, Jianxun Ding, Xuesi Chen. Controlled synthesis of polypeptides[J]. Chinese Chemical Letters, ;2020, 31(12): 3001-3014. doi: 10.1016/j.cclet.2020.04.029 shu

Controlled synthesis of polypeptides

Yang Liu ^{a, b, c} ,
Di Li ^a ,
Jianxun Ding ^{a, c, *,} ,
Xuesi Chen ^{a, b, c}

a.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Science and Technology of China, Hefei 230026, China
c.
Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

jxding@ciac.ac.cn

Received Date: 13 February 2020
Revised Date: 13 April 2020
Accepted Date: 15 April 2020
Available Online: 23 April 2020

Figures(15)

Polypeptides are one kind of promising biodegradable and biocompatible biomedical polymers with the structural units of various α-amino acids. Polypeptides were first polymerized by the ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) by Leuchs and Hermann in 1906. In the past decades, several effective strategies, including the selection of initiators, the adjustment of reaction conditions, and the introduction of catalysts, have been reported to improve the controllability of the ROP of various α-amino acid NCAs to synthesize different polypeptides with precise chemical structures and low polydispersity indexes. In this Review, the strategies, mechanisms, challenges, and opportunities for controlled synthesis of polypeptides by the ROP of different α-amino acid NCAs have been declared.
- α-Amino acid N-carboxyanhydride,
- Ring-opening polymerization,
- Controlled synthesis,
- Polypeptide,
- Biomedical application
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