Citation: Huang Yixing, Yu Xingfang, He Linjie, Liao Xin, Wang Shuo, Qian Zhiyong, Shen Liyan. 3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering[J]. Chinese Chemical Letters, ;2020, 31(7): 1797-1800. doi: 10.1016/j.cclet.2020.01.039 shu

3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering

Huang Yixing ^a ,
Yu Xingfang ^a ,
He Linjie ^a ,
Liao Xin ^a ,
Wang Shuo ^b,*, ,
Qian Zhiyong ^c,*, ,
Shen Liyan ^a,*,

a.
Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China
b.
College of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315199, China
c.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China

16140817@qq.com

anderson-qian@163.com

shenliyan@wmu.edu.cn

Received Date: 16 December 2019
Revised Date: 10 January 2020
Accepted Date: 17 January 2020
Available Online: 18 January 2020

Figures(4)

Acellular tissue matrix scaffolds are much closer to tissue's complex natural structure and biological characteristics, thus assess great advantages in cartilage engineering. We used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via crosslinking. Poly (L-lysine)/hyaluronic acid (PLL/HA) multilayer film was then built up onto the surface of the resulting porous scaffold. Furthermore, TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 days. The success of this project will provide a new way for the treatment of articular cartilage defects. Meanwhile, the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials.
- Acellular cartilage matrix scaffold,
- TGF-β3,
- Polyelectrolyte multilayer film,
- Sustainable release
1. [1]
  (a) E. Hunziker, Osteoarthr. Cartilage 7 (1999) 15-28;
  (b) D.A. Sacolick, J.C. Kirven, M.M. Abouljoud, J.S. Wverhart, D.C. Flanigan, J. Knee Surg. 32 (2019) 1102-1110.
2. [2]
  T.M. Simon, D.W. Jackson, Sports Med. Arthrosc. 14 (2006) 146-154. doi: 10.1097/00132585-200609000-00006
3. [3]
  (a) F. Bolland, S. Korossis, S.P. Wilshaw, et al., Biomaterials 28 (2007) 1061-1070;
  (b) L. Flynn, G.D. Prestwich, J.L. Semple, K.A. Woodhouse, Biomaterials 28 (2007) 3834-3842.
4. [4]
  T. Wu, M. Ding, C. Shi, et al., Chin. Chem. Lett. 31 (2020) 617-625. doi: 10.1016/j.cclet.2019.07.033
5. [5]
  Q. Yao, Y.W. Zheng, Q.H. Lan, et al., Mat. Sci. C-Mater. 104 (2019) 109942. doi: 10.1016/j.msec.2019.109942
6. [6]
  (a) S.F. Badylak, Transpl. Immunol. 12 (2004) 367-377;
  (b) Y. Li, Y. Liu, X. Xun, et al., ACS Appl. Mater. Interface 11 (2019) 36359-36370.
7. [7]
  C. Guo, X. Guo, W. Chu, N. Jiang, H. Li, Chin. Chem. Lett. 30 (2019) 1302-1306. doi: 10.1016/j.cclet.2019.02.023
8. [8]
  F. Barry, R.E. Boynton, B. Liu, et al., Exp. Cell Res. 268 (2001) 189-200. doi: 10.1006/excr.2001.5278
9. [9]
  (a) A.K. Asen, L. Goebel, A. Rey-Rice, et al., FASEB J. 32 (2018) 5298-5311;
  (b) Y.R. Chen, Z.X. Zhou, J.Y. Zhang, et al., Front. Chem. 7 (2019) 745.
10. [10]
  G. Decher, Science 77 (1997) 1232-1237.
11. [11]
  (a) C. Picart, Ph. Lavalle, P. Hubert, et al., Langmuir 17 (2001) 7414-7424;
  (b) Q. Tang, Z. Hu, H. Jin, et al., Theranostics 9 (2019) 1125-1143;
  (c) D. Yan, L.L. Qiu, Y.F. Wang, et al., Chin. Chem. Lett. 29 (2018) 922-926.
12. [12]
  (a) M.P. Sousa, E. Arab-Tehrany, F. Cleymand, J.F. Mano, Small 15 (2019) 1901228;
  (b) K.F. Ren, M. Hu, H. Zhang, et al., Prog. Polym. Sci. 92 (2019) 1-34;
  (c) P. Machillot, C. Quintal, F. Dalonneau, et al., Adv. Mater. 30 (2019) 1801097.
13. [13]
  (a) F. Gilde, L. Fourel, R. Guillot, et al., Acta Biomater. 46 (2016) 55-67;
  (b) M. Bouyer, R. Guillot, J. Lavaud, et al., Biomaterials 104 (2016) 168-181.
14. [14]
  (a) A. Ho-Shui-Ling, J. Bolander, L.E. Rustom, et al., Biomaterials 180 (2018) 143-162;
  (b) Q. Wang, J. Xu, H. Jin, et al., Chin. Chem. Lett. 28 (2017) 1801-1807.
1. [1]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
2. [2]
  Chong-Yang Shi , Jian-Xing Gong , Zhen Li , Chao Shu , Long-Wu Ye , Qing Sun , Bo Zhou , Xin-Qi Zhu . Gold-catalyzed intermolecular amination of allyl azides with ynamides: Efficient construction of 3-azabicyclo[3.1.0] scaffold. Chinese Chemical Letters, 2025, 36(2): 109895-. doi: 10.1016/j.cclet.2024.109895
3. [3]
  Uttam Pandurang Patil . Porous carbon catalysis in sustainable synthesis of functional heterocycles: An overview. Chinese Chemical Letters, 2024, 35(8): 109472-. doi: 10.1016/j.cclet.2023.109472
4. [4]
  Liyang Qin , Luna Wu , Jinlin Long . Advancements in photocatalytic hydrogen peroxide synthesis: overcoming challenges for a sustainable future. Chinese Journal of Structural Chemistry, 2025, 44(4): 100545-100545. doi: 10.1016/j.cjsc.2025.100545
5. [5]
  Zhuan Chen , Bo Yang , Jun Li , Kun Du , Jiangchen Fu , Xiao Wu , Jiazhen Cao , Mingyang Xing . Environmentally safe storage and sustained release of hydrogen peroxide utilizing commercial hydrogel. Chinese Chemical Letters, 2025, 36(6): 110320-. doi: 10.1016/j.cclet.2024.110320
6. [6]
  Yujie Wang , Haoran Wang , Yanni Liu , Manhua Peng , Hongwei Fan , Hong Meng . A comprehensive review on the scalable and sustainable synthesis of covalent organic frameworks. Chinese Chemical Letters, 2025, 36(8): 110189-. doi: 10.1016/j.cclet.2024.110189
7. [7]
  Hefei Yang , Le-Cheng Wang , Xiao-Feng Wu . Sustainable carbonylative transformation of alkyl iodides to amides via crosslinking of EDA and XAT. Chinese Chemical Letters, 2025, 36(9): 110843-. doi: 10.1016/j.cclet.2025.110843
8. [8]
  Qiangwei Wang , Huijiao Liu , Mengjie Wang , Haojie Zhang , Jianda Xie , Xuanwei Hu , Shiming Zhou , Weitai Wu . Observation of high ionic conductivity of polyelectrolyte microgels in salt-free solutions. Chinese Chemical Letters, 2024, 35(4): 108743-. doi: 10.1016/j.cclet.2023.108743
9. [9]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
10. [10]
  Zheyi Li , Xiaoyang Liang , Zitong Qiu , Zimeng Liu , Siyu Wang , Yue Zhou , Nan Li . Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel. Chinese Chemical Letters, 2024, 35(11): 109592-. doi: 10.1016/j.cclet.2024.109592
11. [11]
  Yanhua Peng , Xin Yu , Ting Wang . Adaptive nanoconfined Fenton-like reactions: Tailoring carbon pathways for sustainable water treatment and energy harvesting. Chinese Chemical Letters, 2024, 35(12): 110198-. doi: 10.1016/j.cclet.2024.110198
12. [12]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
13. [13]
  Zhixiao Xiong , Shanni Qiu , Yuyu Wang , Houna Duan , Yi Xiao , Yufang Xu , Weiping Zhu , Xuhong Qian . Photocalibrated NO release from the zinc ion fluorescent probe based on naphthalimide and its application in living cells. Chinese Chemical Letters, 2025, 36(4): 110002-. doi: 10.1016/j.cclet.2024.110002
14. [14]
  Qiao Song , Xue Peng , Zhouyu Wang , Leyong Wang . Iron-catalyzed C–H activation: A sustainable approach to efficient organic synthesis. Chinese Chemical Letters, 2025, 36(5): 110869-. doi: 10.1016/j.cclet.2025.110869
15. [15]
  Haoyu Luo , Jinsong Chen , Mengfei Luo , Hui Ma , Shengyan Pu . Heterogeneous Fenton catalytic degradation of nitrobenzene by controlled-release nano calcium peroxide. Chinese Chemical Letters, 2025, 36(6): 110367-. doi: 10.1016/j.cclet.2024.110367
16. [16]
  Yuhan Zhang , Xiao-Lin Zhang , Han Ding , Yuan Xu , Xue-Wei Liu . Catalytic ring-strain release toward a facial and efficient synthesis of versatile C-glycosides. Chinese Chemical Letters, 2025, 36(7): 110560-. doi: 10.1016/j.cclet.2024.110560
17. [17]
  Baoqi Wu , Rongzhi Tang , Zhi-Wei Li , Feng Lin , Zongyu Sun , Huanyu Xia , Lin Jiang , Yu Tan . Selective encapsulation of azo compounds by tetracationic cyclophane in water and photo-controlled reversible release. Chinese Chemical Letters, 2025, 36(9): 110896-. doi: 10.1016/j.cclet.2025.110896
18. [18]
  Xinwen Li , Lili Li , Junqiu Jiang , Wangyang Mei , Zhaoxia Wang , Qingwei Gao , Huimin Zhou , Liangliang Wei , Qingliang Zhao . Seeking breakthroughs in advanced oxidation processes for waste activated sludge dewatering: A critical review of developments, bibliometrics and sustainable solutions. Chinese Chemical Letters, 2025, 36(11): 110847-. doi: 10.1016/j.cclet.2025.110847
19. [19]
  Xueqi Zhang , Han Gao , Jianan Xu , Min Zhou . Polyelectrolyte-functionalized carbon nanocones enable rapid and accurate analysis of Ag nanoparticle colloids. Chinese Chemical Letters, 2025, 36(4): 110148-. doi: 10.1016/j.cclet.2024.110148
20. [20]
  Sheng Zhao , Junjie Lu , Bifu Sheng , Siying Zhang , Hao Li , Jizhang Chen , Xiang Han . High-performance room temperature solid-state lithium battery enabled by PP-PVDF multilayer composite electrolyte. Chinese Chemical Letters, 2025, 36(6): 110008-. doi: 10.1016/j.cclet.2024.110008

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(1541)
HTML views(99)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142