Citation: Luo Jing, Li Ting, Yang Minghui. Detection protein biomarker with gold nanoparticles functionalized hollow mesoporous Prussian blue nanoparticles as electrochemical probes[J]. Chinese Chemical Letters, ;2020, 31(1): 202-204. doi: 10.1016/j.cclet.2019.05.051 shu

Detection protein biomarker with gold nanoparticles functionalized hollow mesoporous Prussian blue nanoparticles as electrochemical probes

Luo Jing ^a ,
Li Ting ^a,* ,
Yang Minghui ^b,*

a.
Department of General Surgery, The Second Xiang-ya Hospital, Central South University, Changsha 410011, China
b.
Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

csu.edu.cn

yangminghui@csu.edu.cn

Received Date: 19 April 2019
Revised Date: 23 May 2019
Accepted Date: 24 May 2019
Available Online: 25 January 2019

Figures(4)

Gold nanoparticles functionalized hollow mesoporous Prussian blue nanoparticles (Au@HMPB NPs) were synthesized and its peroxidase-like activity was explored for electrochemical probe. The Au@HMPB NPs can reduce H₂O₂ at low detection potential of -0.1 V with high sensitivity. After physically adsorption of antibodies onto the gold nanoparticle surface, the functionalized nanoparticles were turned into immuno-probe. The soluble α-chain of interleukin-2 (IL-2) receptor (sCD25) was chosen as a model protein biomarker to test the performance of the probe. sCD25 in the samples were captured and enriched by capture anti-CD25 antibody functionalized magnetic nanospheres. Detection antibody functionalized Au@HMPB can then be linked onto the nanospheres and generate electrochemical current towards H₂O₂ reduction. The electrochemical responses to 1 mmol/L H₂O₂ was increased with the increasing concentration of CD25.
- God nanoparticles,
- Prussian blue,
- Electrochemical,
- Peroxidase,
- CD25
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