Citation: Wu Ri, Wang Huizhen, Hai Luo, Wang Tianzheng, Hou Min, He Dinggeng, He Xiaoxiao, Wang Kemin. A photosensitizer-loaded zinc oxide-polydopamine core-shell nanotherapeutic agent for photodynamic and photothermal synergistic therapy of cancer cells[J]. Chinese Chemical Letters, ;2020, 31(1): 189-192. doi: 10.1016/j.cclet.2019.05.004 shu

A photosensitizer-loaded zinc oxide-polydopamine core-shell nanotherapeutic agent for photodynamic and photothermal synergistic therapy of cancer cells

Wu Ri ^a ,
Wang Huizhen ^b ,
Hai Luo ^b ,
Wang Tianzheng ^b ,
Hou Min ^a ,
He Dinggeng ^a,**, ,
He Xiaoxiao ^b,**, ,
Wang Kemin ^a,b,*,

a.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
b.
Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, College of Biology, Hunan University, Changsha 410082, China

^**

hedinggeng@hnu.edu.cn

xiaoxiaohe@hnu.edu.cn

kmwang@hnu.edu.cn

Received Date: 17 March 2019
Revised Date: 1 May 2019
Accepted Date: 5 May 2019
Available Online: 6 January 2019

Figures(4)

In clinical cancer research, it is quite promising to develop multimodal synergistic therapeutic strategies. Photodynamic and photothermal synergistic therapy is a very desirable multimodal therapy strategy. Herein, we report a facile and simple method to construct a nanotherapeutic agent for photodynamic and photothermal therapy. This nanotherapeutic agent (ZnO@Ce6-PDA) is composed of a ZnO nanoparticle core, an interlayer of photosensitizer chlorin e6 (Ce6) and an outer layer of polydopamine (PDA). Due to the existence of Ce6, the ZnO@Ce6-PDA can efficiently generate singlet oxygen (¹O₂) under 660 nm laser irradiation. Moreover, the ZnO@Ce6-PDA can serve as a photothermal agent, because of the excellent photothermal conversion efficiency of the PDA coating layer in the presence of 780 nm laser. Experiment results demonstrated that the designed nanotherapeutic agent had outstanding phototoxicity upon the combination of laser irradiation at 660 and 780 nm. Thus, our work proves that the ZnO@Ce6-PDA is a promising photodynamic/photothermal dual-modal nanotherapeutic agent for enhanced cancer therapy.
- Ce6,
- Polydopamine,
- Photodynamic therapy,
- Photothermal therapy
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1.
沈阳化工大学材料科学与工程学院沈阳 110142