Citation: Xu Zeyu, Jiang Xingxing, Liu Shuping, Yang Minghui. Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination[J]. Chinese Chemical Letters, ;2020, 31(1): 185-188. doi: 10.1016/j.cclet.2019.04.026 shu

Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination

Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

yangminghui@csu.edu.cn

Received Date: 13 February 2019
Revised Date: 11 April 2019
Accepted Date: 11 April 2019
Available Online: 12 January 2019

Figures(4)

An electrochemical sensor for doxycycline hyclate (DC) detection with high sensitivity and good selectivity is reported. The sensor was fabricated by electro-polymerization of molecularly imprinted polymers (MIPs) in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs/GCE). The MWCNTs can significantly increase the current response of the sensor, leading to enhanced sensitivity. The MIPs provide selective recognition sites for DC detection. The experimental parameters, such as the polymer monomer concentration, supporting electrolyte pH, the time for electro-polymerization and the incubation time of the sensor with DC were optimized. Under optimized experimental conditions, the sensor displayed a linear range of 0.05 μmol/L-0.5 μmol/L towards DC detection, with the detection limit of 1.3×10^-2 μmol/L. The sensor was successfully applied for recovery test of DC in human serum samples.
- Electrochemical sensor,
- Doxcycline hyclate,
- Molecularly imprinted polymers,
- Multi-walled carbon nanotubes,
- Electro-polymerization
1. [1]
  E. Buduneli, S. Vardar-Sengül, N. Buduneli, et al., J. Periodont. 78(2007) 127-134. doi: 10.1902/jop.2007.050451
2. [2]
  M. Mishra, B. Mishra, Acta Pharm. Sin. B 2(2012) 518-526. doi: 10.1016/j.apsb.2012.05.001
3. [3]
  B. Sloan, N. Scheinfeld, Expert Opin. Drug Saf. 7(2008) 571-577. doi: 10.1517/14740338.7.5.571
4. [4]
  D. Vargas-Estrada, J. Gracia-Mora, H. Sumano, Res. Vet. Sci. 84(2008) 477-482. doi: 10.1016/j.rvsc.2007.07.003
5. [5]
  E. Ayaslioglu, E. Erkek, A. Oba, E. Cebecioglu, Aust. Dent. J. 50(2005) 273-275. doi: 10.1111/j.1834-7819.2005.tb00373.x
6. [6]
  F. Stickel, H.K. Seitz, J. Gastrointest. Liver Dis. 22(2013) 189-197.
7. [7]
  S. Thiele-Bruhn, J. Plant Nutr. Soil Sci. 166(2003) 145-167. doi: 10.1002/jpln.200390023
8. [8]
  A. Ito, T. Sato, M. Ota, et al., Antimicrob. Agents Chemother. 62(2018) 1-11.
9. [9]
  H. Ji, H. Sun, X. Qu, Adv. Drug Deliv. Rev. 105(2016) 176-189. doi: 10.1016/j.addr.2016.04.009
10. [10]
  E.Y. Klein, T.P. van Boeckel, E.M. Martinez, et al., Proc. Natl. Acad. Sci. U. S. A. 115(2018) 3463-3470. doi: 10.1073/pnas.1717295115
11. [11]
  E. Patyra, E. Kowalczyk, K. Kwiatek, Bull. Vet. Inst. Pulawy 56(2012) 329-333. doi: 10.2478/v10213-012-0058-5
12. [12]
  G. Islas, J.A. Rodriguez, I. Perez-Silva, J.M. Miranda, I.S. Ibarra, J. Anal. Methods Chem. 2018(2018) 1-7.
13. [13]
  J. Adrian, F. Ferna'ndez, F. Sa'nchez-Baeza, M.P. Marco, J. Agric. Food Chem. 60(2012) 3837-3846. doi: 10.1021/jf2053355
14. [14]
  X. Feng, J. Ashley, T. Zhou, Y. Sun, Microchim. Acta 185(2018) 500-508. doi: 10.1007/s00604-018-2999-8
15. [15]
  J. Tashkhourian, G. Absalan, M. Jafari, S. Zare, Spectroc. Acta A 152(2016) 119-125. doi: 10.1016/j.saa.2015.07.063
16. [16]
  K. Haupt, K. Mosbach, Chem. Rev. 100(2000) 2495-2504. doi: 10.1021/cr990099w
17. [17]
  M. Ulbricht, J. Chromatogr. B 804(2004) 113-125. doi: 10.1016/j.jchromb.2004.02.007
18. [18]
  P. Wang, X. Fu, J. Li, et al., Chin. Chem. Lett. 22(2011) 611-614. doi: 10.1016/j.cclet.2010.12.004
19. [19]
  S. Ansari, Trac-Trends Anal. Chem. 93(2017) 134-151. doi: 10.1016/j.trac.2017.05.015
20. [20]
  A.G. Mayes, Trac-Trends Anal. Chem. 16(1997) 321-332. doi: 10.1016/S0165-9936(97)00037-X
21. [21]
  J. Bai, X. Zhang, Y. Peng, et al., Sensor. Actuat. B-Chem. 238(2017) 420-426. doi: 10.1016/j.snb.2016.07.035
22. [22]
  L. Yang, B. Xu, H. Ye, F. Zhao, B. Zeng, Sensor. Actuat. B-Chem. 251(2017) 601-608. doi: 10.1016/j.snb.2017.04.006
23. [23]
  Z.Z. Yin, S.W. Cheng, L.B. Xu, et al., Biosens. Bioelectron. 100(2018) 565-570. doi: 10.1016/j.bios.2017.10.010
24. [24]
  H. Dai, D. Xiao, H. He, et al., Microchim. Acta 182(2014) 893-908.
25. [25]
  E. Roy, S. Patra, A. Tiwari, R. Madhuri, P.K. Sharma, Biosens. Bioelectron. 89(2017) 234-248. doi: 10.1016/j.bios.2016.02.056
26. [26]
  Y. Yin, L. Yan, Z. Zhang, J. Wang, Talanta 144(2015) 671-679. doi: 10.1016/j.talanta.2015.06.067
27. [27]
  R.H. Baughman, A.A. Zakhidov, W.A. de Heer, Science 297(2002) 787-792. doi: 10.1126/science.1060928
28. [28]
  R.J. Chen, Y. Zhang, D. Wang, H. Dai, J. Am. Chem. Soc. 123(2001) 3838-3839. doi: 10.1021/ja010172b
29. [29]
  H. Wang, S. Yao, Y. Liu, S. Wei, J. Su, G. Hu, Biosens. Bioelectron. 87(2017) 417-421. doi: 10.1016/j.bios.2016.08.092
30. [30]
  L. Zhang, Y. Wen, Y. Yao, et al., Chin. Chem. Lett. 25(2014) 517-522. doi: 10.1016/j.cclet.2013.12.020
31. [31]
  G. Yang, F. Zhao, B. Zeng, Biosens. Bioelectron. 53(2014) 447-452. doi: 10.1016/j.bios.2013.10.029
32. [32]
  F. Wang, L. Zhu, J. Zhang, Sensor. Actuat. B-Chem. 192(2014) 642-647. doi: 10.1016/j.snb.2013.11.037
1. [1]
  Jie Zhou , Chuanxiang Zhang , Changchun Hu , Shuo Li , Yuan Liu , Zhu Chen , Song Li , Hui Chen , Rokayya Sami , Yan Deng . Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg²⁺. Chinese Chemical Letters, 2024, 35(11): 109561-. doi: 10.1016/j.cclet.2024.109561
2. [2]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
3. [3]
  Shuangying Li , Qingxiang Zhou , Zhi Li , Menghua Liu , Yanhui Li . Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor. Chinese Chemical Letters, 2024, 35(5): 108693-. doi: 10.1016/j.cclet.2023.108693
4. [4]
  Xue Zhao , Mengshan Chen , Dan Wang , Haoran Zhang , Guangzhi Hu , Yingtang Zhou . Ultrafine nano-copper derived from dopamine polymerization & synchronous adsorption achieve electrochemical purification of nitrate to ammonia in complex water environments. Chinese Chemical Letters, 2024, 35(8): 109327-. doi: 10.1016/j.cclet.2023.109327
5. [5]
  Zeyu XU , Tongzhou LU , Haibo SHAO , Jianming WANG . Preparation and electrochemical lithium storage performance of porous silicon microsphere composite with metal modification and carbon coating. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1995-2008. doi: 10.11862/CJIC.20240164
6. [6]
  Wei-Jia Wang , Kaihong Chen . Molecular-based porous polymers with precise sites for photoreduction of carbon dioxide. Chinese Chemical Letters, 2025, 36(1): 109998-. doi: 10.1016/j.cclet.2024.109998
7. [7]
  Yi Liu , Peng Lei , Yang Feng , Shiwei Fu , Xiaoqing Liu , Siqi Zhang , Bin Tu , Chen Chen , Yifan Li , Lei Wang , Qing-Dao Zeng . Topologically engineering of π-conjugated macrocycles: Tunable emission and photochemical reaction toward multi-cyclic polymers. Chinese Chemical Letters, 2024, 35(10): 109571-. doi: 10.1016/j.cclet.2024.109571
8. [8]
  Xueling Yu , Lixing Fu , Tong Wang , Zhixin Liu , Na Niu , Ligang Chen . Multivariate chemical analysis: From sensors to sensor arrays. Chinese Chemical Letters, 2024, 35(7): 109167-. doi: 10.1016/j.cclet.2023.109167
9. [9]
  Xiuzheng Deng , Changhai Liu , Xiaotong Yan , Jingshan Fan , Qian Liang , Zhongyu Li . Carbon dots anchored NiAl-LDH@In₂O₃ hierarchical nanotubes for promoting selective CO₂ photoreduction into CH₄. Chinese Chemical Letters, 2024, 35(6): 108942-. doi: 10.1016/j.cclet.2023.108942
10. [10]
  Mingqi Wang , Shixin Fa , Jiate Yu , Guoxian Zhang , Yi Yan , Qing Liu , Qiuyu Zhang . Light-controlled protein imprinted nanospheres with variable recognition specificity. Chinese Chemical Letters, 2025, 36(2): 110124-. doi: 10.1016/j.cclet.2024.110124
11. [11]
  Tian Cao , Xuyin Ding , Qiwen Peng , Min Zhang , Guoyue Shi . Intelligent laser-induced graphene sensor for multiplex probing catechol isomers. Chinese Chemical Letters, 2024, 35(7): 109238-. doi: 10.1016/j.cclet.2023.109238
12. [12]
  Neng Shi , Haonan Jia , Jixiang Zhang , Pengyu Lu , Chenglong Cai , Yixin Zhang , Liqiang Zhang , Nongyue He , Weiran Zhu , Yan Cai , Zhangqi Feng , Ting Wang . Accurate expression of neck motion signal by piezoelectric sensor data analysis. Chinese Chemical Letters, 2024, 35(9): 109302-. doi: 10.1016/j.cclet.2023.109302
13. [13]
  Jiqing Liu , Qi Dang , Liting Wang , Dejin Wang , Liang Tang . Applications of flexible electrochemical electrodes in wastewater treatment: A review. Chinese Chemical Letters, 2024, 35(8): 109277-. doi: 10.1016/j.cclet.2023.109277
14. [14]
  Hao WANG , Kun TANG , Jiangyang SHAO , Kezhi WANG , Yuwu ZHONG . Electro-copolymerized film of ruthenium catalyst and redox mediator for electrocatalytic water oxidation. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2193-2202. doi: 10.11862/CJIC.20240176
15. [15]
  Li Li , Zhi-Xin Yan , Chuan-Kun Ran , Yi Liu , Shuo Zhang , Tian-Yu Gao , Long-Fei Dai , Li-Li Liao , Jian-Heng Ye , Da-Gang Yu . Electro-reductive carboxylation of CCl bonds in unactivated alkyl chlorides and polyvinyl chloride with CO₂. Chinese Chemical Letters, 2024, 35(12): 110104-. doi: 10.1016/j.cclet.2024.110104
16. [16]
  Hailong He , Wenbing Wang , Wenmin Pang , Chen Zou , Dan Peng . Double stimulus-responsive palladium catalysts for ethylene polymerization and copolymerization. Chinese Chemical Letters, 2024, 35(7): 109534-. doi: 10.1016/j.cclet.2024.109534
17. [17]
  Bohan Zhang , Bingzhe Wang , Guichuan Xing , Zikang Tang , Songnan Qu . Regulation of the multi-emission centers in carbon dots via a bottom-up synthesis approach. Chinese Chemical Letters, 2024, 35(9): 109358-. doi: 10.1016/j.cclet.2023.109358
18. [18]
  Yuhao Guo , Na Li , Tingjiang Yan . Tandem catalysis for photoreduction of CO2 into multi-carbon fuels on atomically thin dual-metal phosphochalcogenides. Chinese Journal of Structural Chemistry, 2024, 43(7): 100320-100320. doi: 10.1016/j.cjsc.2024.100320
19. [19]
  Yupeng Liu , Hui Wang , Songnan Qu . Review on near-infrared absorbing/emissive carbon dots: From preparation to multi-functional application. Chinese Chemical Letters, 2025, 36(5): 110618-. doi: 10.1016/j.cclet.2024.110618
20. [20]
  Yunfei Shen , Long Chen . Gradient imprinted Zn metal anodes assist dendrites-free at high current density/capacity. Chinese Journal of Structural Chemistry, 2024, 43(10): 100321-100321. doi: 10.1016/j.cjsc.2024.100321

Get Citation

PDF

XML

Metrics

PDF Downloads(16)
Abstract views(1037)
HTML views(56)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142