Citation: Huang Xi, Yin Yanlong, Wu Min, Zan Wang, Yang Qian. LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia[J]. Chinese Chemical Letters, ;2019, 30(6): 1335-1340. doi: 10.1016/j.cclet.2019.02.019 shu

LyP-1 peptide-functionalized gold nanoprisms for SERRS imaging and tumor growth suppressing by PTT induced-hyperthermia

Huang Xi ^a,b,1 ,
Yin Yanlong ^a ,
Wu Min ^a ,
Zan Wang ^a ,
Yang Qian ^a,*,

a.
The School of Pharmacy, College Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu 610500, China
b.
Ophthalmic Laboratory and Department of Ophthalmology, State Key Laboratory and Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

yoyoyoung8293@gmail.com

Received Date: 29 December 2018
Revised Date: 10 February 2018
Accepted Date: 21 February 2018
Available Online: 21 June 2018

Figures(5)

Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPsbased nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
- Gold nanoprisms,
- SERRS imaging,
- LyP-1 peptide,
- Tumor targeting,
- Photothermal therapy
1. [1]
  W. Zhou, X. Gao, D.B. Liu, X.Y. Chen, Chem. Rev. 115(2015) 10575-10636. doi: 10.1021/acs.chemrev.5b00100
2. [2]
  C. Zhou, J.Q. Huang, Q. Yang, et al., Colloids Surf. B Biointerfaces 171(2018) 17-23. doi: 10.1016/j.colsurfb.2018.07.002
3. [3]
  Q. Yang, J.R. Peng, Y. Xiao, et al., ACS Appl. Mater. Interfaces 10(2018) 150-164. doi: 10.1021/acsami.7b14705
4. [4]
  L.A. Lane, R. Xue, S. Nie. Curr. Opin. Chem. Biol. 45(2018) 95-103. doi: 10.1016/j.cbpa.2018.03.015
5. [5]
  H.D. Cui, D.H. Hu, J.N. Zhang, et al., Chin. Chem. Lett. 28(2017) 1391-1398. doi: 10.1016/j.cclet.2016.12.038
6. [6]
  H. Lei, Y. Hu, G. Li, Chin. Chem. Lett. 29(2018) 509-512. doi: 10.1016/j.cclet.2017.08.012
7. [7]
  Y. Wang, Q. Yang, S. Kang, M.A. Wall, J.T.C. Liu, J. Biomed. Opt. 23(2018) 1-8.
8. [8]
  M.W. Li, Y.Y. Qiu, C.C. Fan, et al., Acta Pharma. Sin. B 8(2018) 381-389. doi: 10.1016/j.apsb.2018.01.010
9. [9]
  H. Yuan, Y. Liu, A.M. Fales, et al., Anal. Chem. 85(2013) 208-212. doi: 10.1021/ac302510g
10. [10]
  M. Pérez-Hernández, P. del Pino, S.G. Mitchell, et al., ACS Nano 9(2015) 52-61. doi: 10.1021/nn505468v
11. [11]
  S.Q. Yang, L.Z. Zhou, Y. Su, R. Zhang, C.M. Dong, Chin. Chem. Lett. 30(2019) 187-191. doi: 10.1016/j.cclet.2018.02.015
12. [12]
  Y. Zhao, W. Liu, Y. Tian, et al., ACS Appl. Mater. Interfaces 10(2018) 16992-17003. doi: 10.1021/acsami.7b19013
13. [13]
  C. Kuttner, M. Mayer, M. Dulle, et al., ACS Appl. Mater. Interfaces 10(2018) 11152-11163. doi: 10.1021/acsami.7b19081
14. [14]
  V. Fogal, L. Zhang, S. Krajewski, E. Ruoslahti, Cancer Res. 68(2008) 7210-7218. doi: 10.1158/0008-5472.CAN-07-6752
15. [15]
  Z.Q. Yan, F. Wang, Z.Y. Wen, et al., J. Control. Release 157(2012) 118-125. doi: 10.1016/j.jconrel.2011.07.034
16. [16]
  L. Paasonen, S. Sharma, G.B. Braun, et al., ChemBioChem 17(2016) 570-575. doi: 10.1002/cbic.v17.7
17. [17]
  Y. Jiang, S. Liu, Y. Zhang, et al., Biomaterials 115(2017) 9-18. doi: 10.1016/j.biomaterials.2016.11.006
18. [18]
  S. Harmsen, M.A. Wall, R. Huang, M.F. Kircher, Nat. Protoc. 12(2017) 1400. doi: 10.1038/nprot.2017.031
19. [19]
  T. Nagy-Simon, M. Potara, A.M. Craciun, E. Licarete, S. Astilean, J. Colloid Interf. Sci. 517(2018) 239-250. doi: 10.1016/j.jcis.2018.02.007
20. [20]
  F.R. Tian, J. Conde, C.C. Bao, et al., Biomaterials 106(2016) 87-97. doi: 10.1016/j.biomaterials.2016.08.014
21. [21]
  J.V. Jokerst, A.J. Cole, D. Van de Sompel, S.S. Gambhir, ACS Nano 6(2012) 10366-10377. doi: 10.1021/nn304347g
22. [22]
  Y.P. Jia, B.Y. Ma, X.W. Wei, Z.Y. Qian, Chin. Chem. Lett. 28(2017) 691-702. doi: 10.1016/j.cclet.2017.01.021
23. [23]
  X.C. Tang, L.W. Tan, K. Shi, et al., Acta Pharma. Sin. B 8(2018) 587-601. doi: 10.1016/j.apsb.2018.05.011
24. [24]
  M.A. Escudero-Francos, V. Cepas, P. González-Menéndez, et al., J. Biomed. Nanotechnol. 13(2017) 167-179. doi: 10.1166/jbn.2017.2344
25. [25]
  F.C. Tian, F.Z. Fatima, J.N. Qiao, et al., Acta Biomater. 75(2018) 398-412. doi: 10.1016/j.actbio.2018.05.050
1. [1]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
2. [2]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
3. [3]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
4. [4]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
5. [5]
  Ying Gao , Rong Zhou , Qiwen Wang , Shaolong Qi , Yuanyuan Lv , Shuang Liu , Jie Shen , Guocan Yu . Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy. Chinese Chemical Letters, 2024, 35(10): 109521-. doi: 10.1016/j.cclet.2024.109521
6. [6]
  Qianyun Ye , Yuanyuan Liang , Yuhe Yuan , Xiaohuan Sun , Liqi Zhu , Xuan Wu , Jie Han , Rong Guo . pH-responsive chiral supramolecular cysteine-Zn²⁺-indocyanine green assemblies for triple-level chirality-specific anti-tumor efficacy. Chinese Chemical Letters, 2025, 36(5): 110432-. doi: 10.1016/j.cclet.2024.110432
7. [7]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
8. [8]
  Tianze Wang , Junyi Ren , Dongxiang Zhang , Huan Wang , Jianjun Du , Xin-Dong Jiang , Guiling Wang . Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY. Chinese Chemical Letters, 2024, 35(6): 108862-. doi: 10.1016/j.cclet.2023.108862
9. [9]
  Xiao-Fang Lv , Xiao-Yun Ran , Yu Zhao , Rui-Rui Zhang , Li-Na Zhang , Jing Shi , Ji-Xuan Xu , Qing-Quan Kong , Xiao-Qi Yu , Kun Li . Combing NIR-Ⅱ molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency. Chinese Chemical Letters, 2025, 36(4): 110027-. doi: 10.1016/j.cclet.2024.110027
10. [10]
  Yongkang Yue , Zhou Xu , Kaiqing Ma , Fangjun Huo , Xuemei Qin , Kuanshou Zhang , Caixia Yin . HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials. Chinese Chemical Letters, 2024, 35(8): 109223-. doi: 10.1016/j.cclet.2023.109223
11. [11]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
12. [12]
  Songtao Cai , Liuying Wu , Yuan Li , Soham Samanta , Jinying Wang , Bing Liu , Feihu Wu , Kaitao Lai , Yingchao Liu , Junle Qu , Zhigang Yang . Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye. Chinese Chemical Letters, 2024, 35(4): 108599-. doi: 10.1016/j.cclet.2023.108599
13. [13]
  Yupeng Liu , Hui Wang , Songnan Qu . Review on near-infrared absorbing/emissive carbon dots: From preparation to multi-functional application. Chinese Chemical Letters, 2025, 36(5): 110618-. doi: 10.1016/j.cclet.2024.110618
14. [14]
  Di An , Mingdong She , Ziyang Zhang , Ting Zhang , Miaomiao Xu , Jinjun Shao , Qian Shen , Xuna Tang . Light-responsive nanomaterials for biofilm removal in root canal treatment. Chinese Chemical Letters, 2025, 36(2): 109841-. doi: 10.1016/j.cclet.2024.109841
15. [15]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
16. [16]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
17. [17]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
18. [18]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
19. [19]
  Ze Wang , Hao Liang , Annan Liu , Xingchen Li , Lin Guan , Lei Li , Liang He , Andrew K. Whittaker , Bai Yang , Quan Lin . Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer. Chinese Chemical Letters, 2025, 36(2): 109765-. doi: 10.1016/j.cclet.2024.109765
20. [20]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(809)
HTML views(14)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142