Citation: Zhang Yujiao, Xie Kebo, Liu Aijing, Chen Ridao, Chen Dawei, Yang Lin, Dai Jungui. Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius[J]. Chinese Chemical Letters, ;2019, 30(2): 443-446. doi: 10.1016/j.cclet.2018.05.010 shu

Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius

Zhang Yujiao ^a,1 ,
Xie Kebo ^b,1 ,
Liu Aijing ^a ,
Chen Ridao ^b ,
Chen Dawei ^b ,
Yang Lin ^a,*, ,
Dai Jungui ^b,*,

a.
College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
b.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

15116995486@163.com

jgdai@imm.ac.cn

Received Date: 21 March 2018
Revised Date: 3 May 2018
Accepted Date: 4 May 2018
Available Online: 5 February 2018

Figures(3)

Enzymatic glycosylation catalyzed by glycosyltransferases (GTs) has great potential in creating diverse novel and bioactive glycosides. Herein, three new GTs (UGT84A33, UGT71AE1 and UGT90A14) from Carthamus tinctorius exhibited robust catalytic promiscuity to benzylisoquinoline alkaloids, and were used as enzymatic tools in glycosylation of bioactive benzylisoquinoline alkaloids. Seven novel benzylisoquinoline alkaloids O-glycosides were synthesized with high efficiency. These studies indicate the significant potential of promiscuous GTs in synthesis of benzylisoquinoline alkaloids glycosides for drug discovery.
- Glycosyltransferase,
- Catalytic promiscuity,
- Benzylisoquinoline alkaloids,
- Carthamus tinctorius
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