Citation: Yang Siqi, Zhou Linzhu, Su Yue, Zhang Rong, Dong Chang-Ming. One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy[J]. Chinese Chemical Letters, ;2019, 30(1): 187-191. doi: 10.1016/j.cclet.2018.02.015 shu

One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy

Yang Siqi ^a ,
Zhou Linzhu ^a ,
Su Yue ^a ,
Zhang Rong ^b,*,, ,
Dong Chang-Ming ^a,b,*,,

a.
School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China
b.
Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital, Shanghai 201400, China

Corresponding author: Zhang Rong, rongzhang@163.com Dong Chang-Ming, cmdong@sjtu.edu.cn

Received Date: 29 December 2017
Revised Date: 1 February 2018
Accepted Date: 24 February 2018
Available Online: 6 January 2018

Figures(4)

We developed one-pot photoreduction strategy to prepare near infrared light (NIR)-absorbing plasmonic gold nanoparticles (Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly (ethylene oxide) (PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700-1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation (808 nm, 2 W/cm², 5 min), the PLC-b-PEO@Au NPs (1 mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin (DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy (CT) or photothermal therapy (PT), demonstrating a synergistic effect.
- Near infrared,
- Plasmonic gold nanoparticles,
- Polypeptide,
- Photothermal therapy,
- Combination therapy
1. [1]
  X. Yang, M. Yang, B. Pang, et al., Chem. Rev. 115(2015) 10410-10488. doi: 10.1021/acs.chemrev.5b00193
2. [2]
  W. Zhou, X. Gao, D. Liu, et al., Chem. Rev. 115(2015) 10575-10636. doi: 10.1021/acs.chemrev.5b00100
3. [3]
  S. Lal, S.E. Clare, N.J. Halas, Acc. Chem. Res. 41(2008) 1842-1851. doi: 10.1021/ar800150g
4. [4]
  A. Liu, G. Wang, F. Wang, et al., Coord. Chem. Rev. 336(2017) 28-42. doi: 10.1016/j.ccr.2016.12.019
5. [5]
  L. Cheng, C. Wang, L. Feng, et al., Chem. Rev. 114(2014) 10869-10939. doi: 10.1021/cr400532z
6. [6]
  Z. Zhang, J. Wang, C.Y. Chen, Adv. Mater. 25(2013) 3869-3880. doi: 10.1002/adma.v25.28
7. [7]
  R.F. Zhao, X.X. Han, Y.Y. Li, et al., ACS Nano 11(2017) 8103-8113. doi: 10.1021/acsnano.7b02918
8. [8]
  N. Zhang, D.X. Zhu, L. Feng, et al., J. Biomed. Nanotechnol. 13(2017) 134-143. doi: 10.1166/jbn.2017.2330
9. [9]
  H.F. Deng, Y. Dai, G.H. Ma, et al., Adv. Mater. 27(2015) 3645-3653. doi: 10.1002/adma.201501420
10. [10]
  S. Chen, Q. Lei, W.X. Qiu, et al., Biomaterials 117(2017) 92-104. doi: 10.1016/j.biomaterials.2016.11.056
11. [11]
  L. Wang, Y.Y. Yuan, S.D. Lin, et al., Biomaterials 78(2016) 40-49. doi: 10.1016/j.biomaterials.2015.11.024
12. [12]
  X. Wu, L. Zhou, Y. Su, et al., Biomacromolecules 17(2016) 2489-2501. doi: 10.1021/acs.biomac.6b00721
13. [13]
  Q. Yang, J.R. Peng, Y. Xiao, et al., ACS Appl. Mater. Interfaces. 10(2018) 150-164. doi: 10.1021/acsami.7b14705
14. [14]
  J.B. Song, P. Huang, H.W. Duan, et al., Acc. Chem. Res. 48(2015) 2506-2515. doi: 10.1021/acs.accounts.5b00059
15. [15]
  Y. Liu, Y. Liu, J. Yin, et al., Macromol. Rapid. Commun. 36(2015) 711-725. doi: 10.1002/marc.v36.8
16. [16]
  K. Jiang, D.A. Smith, A. Pinchuk, J. Phys. Chem. 117(2013) 27073-27080.
17. [17]
  S.E. And, M.A. Elsayed, J. Phys. Chem. 110(2006) 14014-14019. doi: 10.1021/jp062972k
18. [18]
  Y.F. Huang, S.C. Lu, Y.C. Huang, et al., Small 10(2014) 1939-1944. doi: 10.1002/smll.201303462
19. [19]
  H. Cabral, N. Nishiyama, K. Kataoka, Acc. Chem. Res. 44(2011) 999-1008. doi: 10.1021/ar200094a
20. [20]
  C. Deng, J.T. Wu, R. Cheng, et al., Prog. Polym. Sci. 39(2014) 330-364. doi: 10.1016/j.progpolymsci.2013.10.008
21. [21]
  X. Wu, L. Zhou, Y. Su, et al., Polym. Chem. 7(2016) 5552-5562. doi: 10.1039/C6PY01189F
22. [22]
  B.W. Zhao, Z.X. Zhou, Y.Q. Shen, Chin. J. Polym. Sci. 34(2016) 94-103. doi: 10.1007/s10118-016-1735-2
23. [23]
  Y. Bustami, M. Moo-Young, W.A. Anderson, Sensor. Actuat. B-Chem. 245(2017) 753-764.
24. [24]
  L. Ma, M. Kohli, A. Smith, ACS Nano 7(2013) 9518-9525. doi: 10.1021/nn405674m
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2. [2]
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12. [12]
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13. [13]
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16. [16]
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