Citation: Zhao Yunfang, Huang Zheng, Sun Jing, Pang Daoran, Chen Xiaonan, Yao Huina, Zhu Zhixiang, Zheng Jiao, Tu Pengfei, Li Jun. Diterpenoids from the aerial parts of Leonurus macranthus[J]. Chinese Chemical Letters, ;2019, 30(1): 47-50. doi: 10.1016/j.cclet.2017.11.033 shu

Diterpenoids from the aerial parts of Leonurus macranthus

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China

Corresponding author: Li Jun, drlj666@163.com

Received Date: 26 October 2017
Revised Date: 23 November 2017
Accepted Date: 24 November 2017
Available Online: 26 January 2017

Figures(3)

Four new diterpenoids including one cis clerodane-type (1) and three highly oxygenated labdane-type diterpenes (2-4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data (NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC₅₀ values of 35.8±3.6 mmol/L and 48.6±4.8 mmol/L, respectively
- Lamiaceae,
- Labdane diterpenoid,
- cis-Clerodane diterpenoid,
- Anti-neuroinflammation
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