Citation: Ruan Jun, Zhang Wenbo, Zhang Hang, Chen Yun, Ur Rehman Fawad, Jiang Hui, Strehle Steffen, Pasquarelli Alberto, Wang Xuemei. Highly sensitive electrochemical detection of living cells based on diamond microelectrode arrays[J]. Chinese Chemical Letters, ;2018, 29(6): 919-921. doi: 10.1016/j.cclet.2017.10.037 shu

Highly sensitive electrochemical detection of living cells based on diamond microelectrode arrays

a.
State Key Laboratory of Bioelectronics(Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
b.
Institute of Electron Devices and Circuits, Ulm University, Ulm 89069, Germany

Corresponding author: Pasquarelli Alberto, alberto.pasquarelli@uni-ulm.de Wang Xuemei, xuewang@seu.edu.cn

Received Date: 13 April 2017
Revised Date: 26 October 2017
Accepted Date: 27 October 2017
Available Online: 28 June 2017

Figures(3)

We designed boron-doped nanocrystalline diamond microelectrode arrays (BNCD-MEAs) with 16 channels for the bioanalysis of multicellular samples, which could be readily adapted for a highly sensitive detection of H₂O₂ released from stimulated cells by ascorbic acid (AA). Our observations demonstrated that the as-prepared diamond microelectrode arrays could be utilized to distinguish cancer cells from normal cells, and the amperometric study showed the considerable differences in the currents, indicating that the related HepG2 cancer cells could release more H₂O₂ than that of L02 normal cells. This supports the possibility to use diamond-based MEAs for rapid cancer cell detection in future clinic applications.
- BNCD-MEAs,
- 16 Channels,
- Bioanalysis,
- Stimulated cells,
- H₂O₂ detection
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1.
沈阳化工大学材料科学与工程学院沈阳 110142