Citation: Cheng Bin, Yuki Hirokami, Li Yi-Xian, Atsushi Kato, Jia Yue-Mei, Yu Chu-Yi. Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives[J]. Chinese Chemical Letters, ;2017, 28(8): 1701-1704. doi: 10.1016/j.cclet.2017.06.016 shu

Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

Cheng Bin ^a,b ,
Yuki Hirokami ^c ,
Li Yi-Xian ^a,b,**,, ,
Atsushi Kato ^c,, ,
Jia Yue-Mei ^a,b ,
Yu Chu-Yi ^a,b,d,**,,

a.
Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
University of Chinese Academy of Sciences, Beijing 100049 China
c.
Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan
d.
National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China

Corresponding author: Li Yi-Xian, tamarali@iccas.ac.cn Atsushi Kato, kato@med.u-toyama.ac.jp Yu Chu-Yi, yucy@iccas.ac.cn

^**

Received Date: 9 May 2017
Revised Date: 24 May 2017
Accepted Date: 12 June 2017
Available Online: 15 August 2017

Figures(3)

A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.
- Nitrone,
- 1, 3-Dipolar cycloaddition,
- Ammonolysis,
- Glycosidase inhibitors,
- Polyhydroxylated pyrrolizidines
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