Citation: Arshad Mohammad, Roouf Bhat Abdul, Kang Hoi Kwon, Choi Inho, Athar Fareeda. Synthesis, characterization and antibacterial screening of some novel 1, 2, 4-triazine derivatives[J]. Chinese Chemical Letters, ;2017, 28(7): 1559-1565. doi: 10.1016/j.cclet.2016.12.037 shu

Synthesis, characterization and antibacterial screening of some novel 1, 2, 4-triazine derivatives

a.
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India
b.
College of Medicine Aldawadmi Shaqra University, Saudi Arabia
c.
P. G. Department of Chemistry, Sri Pratap College, Srinagar, J & K, 190001, India
d.
School of Biotechnology, Yeungnam University, Gyeongsan 712-749, South Korea

Corresponding author: Athar Fareeda, fathar@jmi.ac.in
Received Date: 23 August 2016
Revised Date: 1 November 2016
Accepted Date: 28 November 2016
Available Online: 9 July 2017

Figures(3)

A new series of 1, 2, 4-triazine derivatives possessing indole nucleus were synthesized with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. In vitro antimicrobial activity was performed against S. aureus, S. epidermidis, P. mirabilis and E. coli using disk diffusion method. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibition area/μg of the compounds with the standard drug "Ciprofloxacin". Selected compounds were evaluated for toxic effects using human hepatocellular carcinoma (HepG2) cell line by MTT-assay. Results revealed that some compounds of the series were found to exhibit better activity with less toxicity than Ciprofloxacin.
- Synthesis,
- 1, 2, 4-Triazine,
- Antibacterial activity,
- Toxic effects,
- MTT-assay
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沈阳化工大学材料科学与工程学院沈阳 110142