Citation: Soliman Hanan A., Khatab Tamer K., Abdel-Megeid Farouk M. E. . Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile[J]. Chinese Chemical Letters, ;2016, 27(9): 1515-1518. doi: 10.1016/j.cclet.2016.03.026 shu

Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile

a.
Photochemistry Department, National Research Centre, Dokki 12622, Egypt
b.
Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Egypt

Corresponding author: Soliman Hanan A., tarek12_2@yahoo.com
Received Date: 24 January 2016
Revised Date: 15 March 2016
Accepted Date: 16 March 2016
Available Online: 24 September 2016

Figures(5)

An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN₃ from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1, 2-bromoazides. Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches. 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
- Azidobromination,
- Tetrachlorosilane,
- Arylidene malononitrile,
- Sodium azide,
- N-Bromosuccinimide
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