Citation: Guo-Ping Zeng, Chang-Quan Cai, Fen Tan, Ming-Wu Ding. New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane[J]. Chinese Chemical Letters, ;2015, 26(9): 1158-1160. doi: 10.1016/j.cclet.2015.06.011 shu

New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane

1.
1 Hubei Province Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Hubei University of Education, Wuhan 430205, China;
2.
2 Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China

Corresponding author: Ming-Wu Ding,
Received Date: 3 April 2015
Available Online: 11 May 2015
Fund Project: We gratefully acknowledge financial support of this work by the National Natural Science Foundation of China (No. 21172085) (No. 21172085) the Natural Science Foundation of Hubei Province (No. 2014CFB567) (No. 2014CFB567)

A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. The sequential three-component reaction of oxazolyliminophosphorane 4, isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones 7 in good overall yields in the presence of catalytic amount of EtONa.
- Oxazolo[5,4-d]pyrimidi-7(6H)-one,
- Aza-Wittig reaction,
- Iminophosphorane,
- Carbodiimide
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