Citation: Alaa A. Hassan, Fathy F. Abdel-Latif, Mohamed Abdel Aziz, Sara M. Mostafa, Stefan Bräse, Martin Nieger. Heterocyclization of thiocarbonohydrazides: Facile synthesis of 5-unsubstituted-1,3,4-thiadiazoles[J]. Chinese Chemical Letters, ;2015, 26(9): 1183-1186. doi: 10.1016/j.cclet.2015.05.034 shu

Heterocyclization of thiocarbonohydrazides: Facile synthesis of 5-unsubstituted-1,3,4-thiadiazoles

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1 Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt;
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2 Department of Medicinal Chemistry, Faculty of Pharmacy, El-Minia University, 61519 El-Minia, Egypt;
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3 Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany;
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4 Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, 00014 Helsinki, Finland

Corresponding author: Alaa A. Hassan,
Received Date: 4 February 2015
Available Online: 22 April 2015

2-(Hydrazinecarbothioyl)-N-substituted hydrazinecarbothioamides react with 2,3,5,6-tetrachloro-1,4-benzoquinone in high yields in a novel fast and facile method to give 5-unsubstituted-1,3,4-thiadiazole-2-amine derivatives. The synthesized compounds were characterized by spectroscopic methods and confirmed by using X-ray crystallography. A rationale for the formation of the products is presented.
- Thiocarbonohydrazides,
- 5-Unsubstituted 1,3,4-thiadiazol-2-amines,
- Tetrachloro-1,4-benzoquinone,
- X-ray crystallography
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