Citation: Alexander K. Wolf, Yu Qin, Terry C. Major, Mark E. Meyerhoff. Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings[J]. Chinese Chemical Letters, ;2015, 26(4): 464-468. doi: 10.1016/j.cclet.2015.03.002 shu

Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

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a Department of Chemistry, University of Michigan, Ann Arbor, MI, USA;
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b Department of Chemistry, Nanjing University, Nanjing 210093, China;
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c Department of Surgery, University of Michigan, Ann Arbor, MI, USA

Corresponding author: Mark E. Meyerhoff,
Received Date: 12 December 2014
Available Online: 15 January 2015
Fund Project:

In this work, nitric oxide (NO) release coatings designed for intravenous amperometric glucose sensors are optimized through the use of a polylactic acid (PLA) layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An Elast-Eon E2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor's linear detection range toward glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.
- Nitric oxide release coatings,
- Glucose sensors,
- Polylactic acid layer,
- Quantitative glucose measurements
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沈阳化工大学材料科学与工程学院沈阳 110142