Citation: Ren-Min Wu, Na Qi, Yu-Wen Jia, Zhu Guan, Liang-Ren Zhang, Li-He Zhang, Zhen-Jun Yang. A novel method for the synthesis of sulfur substitutedcyclopyrophosphate of cADPR analogs[J]. Chinese Chemical Letters, ;2014, 25(12): 1583-1585. doi: 10.1016/j.cclet.2014.07.010 shu

A novel method for the synthesis of sulfur substitutedcyclopyrophosphate of cADPR analogs

1.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Zhen-Jun Yang,
Received Date: 3 June 2014
Available Online: 14 July 2014
Fund Project: Weare grateful for scientific research funding from the National Natural Science Foundation of China (Nos. 21332010, 21172010, 21002004). (Nos. 21332010, 21172010, 21002004)

A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE (P_S¹-cIDPRE) was developed. The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.
- cADPR,
- cIDPRE,
- Phosphoramidite strategy,
- Cyclopyrophosphate
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沈阳化工大学材料科学与工程学院沈阳 110142