Citation: Hong Yu, Yi-Meng Sun, Chun-Miao Zou. Imidazolium ionic liquid as the background ultraviolet absorption reagent for determination of morpholinium cations by high performance liquid chromatography-indirect ultraviolet detection[J]. Chinese Chemical Letters, ;2014, 25(10): 1371-1374. doi: 10.1016/j.cclet.2014.05.041 shu

Imidazolium ionic liquid as the background ultraviolet absorption reagent for determination of morpholinium cations by high performance liquid chromatography-indirect ultraviolet detection

1.
College of Chemistry and Chemical Engineering, Harbin Normal University and Key Laboratory of Photonic and Electronic Bandgap Materials, Ministry of Education, Harbin 150025, China

Corresponding author: Hong Yu,
Received Date: 25 March 2014
Available Online: 30 April 2014
Fund Project: This work was supported by the Natural Science Foundation of Heilongjiang Province (No. B201307) (No. B201307) the Ministry of Education of Heilongjiang Province (No. 12531192) (No. 12531192)

A novel analytical method was developed for determining morpholinium cations lacking ultraviolet absorption groups. This determination was carried out by high performance liquid chromatography-indirect ultraviolet (HPLC-IUV) detection using imidazolium ionic liquid as background absorption reagents, and imidazolium ionic liquid aq. soln.-organic solvent as mobile phase by a reversed-phase C18 column. The background ultraviolet absorption reagents, imidazolium ionic liquids and organic solvents were investigated. The imidazolium ionic liquid in the mobile phase is not only the background ultraviolet absorption reagent for IUV, but also an active component to improve the separation of morpholinium cations. It was found that morpholinium cations could be adequately determined when 0.5 mmol/L 1-ethyl-3-methylimidazolium tetrafluoroborate aq. soln./methanol (80:20, v/v) was used as mobile phase with an IUV detection wavelength of 210 nm. In this study, the baseline separation of Nmethyl, ethylmorpholinium cations (MEMo) and N-methyl, propylmorpholinium cations (MPMo) was successfully achieved in 8.5 min. The detection limits (S/N = 3) for MEMo and MPMo were 0.15 and 0.29 mg/L, respectively. This simple and practical method has been successfully applied to the determination of two morpholinium ionic liquids synthesized by the chemistry laboratory.
- High performance liquid chromatography,
- Indirect ultraviolet detection,
- Imidazolium ionic liquids,
- Morpholinium cations
1. [1]
  [1] R.Q. Zhang, H. Yu, X.J. Sun, Separation and determination of pyrrolidinium ionic liquid cations by ion chromatography with direct conductivity detection, Chin. Chem. Lett. 24 (2013) 503-505.
2. [2]
  [2] T.D. Ho, C. Zhang, L.W. Hantao, J.L. Anderson, Ionic liquids in analytical chemistry: fundamentals, advances, and perspectives, Anal. Chem. 86 (2014) 262-285.
3. [3]
  [3] W. Gao, H. Yu, S. Zhou, Applications of ionic liquids in chromatographic analysis and determination of ionic liquids by chromatography, Chin. J. Chromatogr. 28 (2010) 14-22.
4. [4]
  [4] K.P. Boroujeni, M. Jafarinasab, Polystyrene-supported pyridinium chloroaluminate ionic liquid as a new heterogeneous Lewis acid catalyst for Knoevenagel condensation, J. Chem. Res. 36 (2012) 429-431.
5. [5]
  [5] M. Paszkiewicz, P. Stepnowski, How should ionic liquids be analyzed? Curr. Org. Chem. 15 (2011) 1873-1887.
6. [6]
  [6] C.M. Zou, H. Yu, M.Y. Wang, Determination of tetraethyl ammonium by ion-pair chromatography with indirect ultraviolet detection using 4-aminophenol hydrochloride as background ultraviolet absorbing reagent, Chin. Chem. Lett. 25 (2014) 201-204.
7. [7]
  [7] B. Buszewski, S. Kowalska, P. Stepnowski, Influence of stationary phase properties on the separation of ionic liquid cations by RP-HPLC, J. Sep. Sci. 29 (2006) 1116-1125.
8. [8]
  [8] M.J. Ruiz-Angel, A. Berthod, Reversed phase liquid chromatography of alkylimidazolium ionic liquids, J. Chromatogr. A 1113 (2006) 101-108.
9. [9]
  [9] M.J. Ruiz-Angel, A. Berthod, Reversed-phase liquid chromatography analysis of alkyl-imidazolium ionic liquids II. Effects of different added salts and stationary phase influence, J. Chromatogr. A 1189 (2008) 476-482.
10. [10]
  [10] W. Gao, H. Yu, Determination of homologue imidazolium ionic liquid cations by ion chromatography using a carboxyl acid cation-exchange column with direct conductivity detection, Anal. Lett. 44 (2011) 922-931.
11. [11]
  [11] X. Huang, H. Yu, Y.J. Dong, Rapid and simultaneous determination of imidazolium and pyridinium ionic liquid cations by ion-pair chromatography using a monolithic column, Chin. Chem. Lett. 23 (2012) 843-846.
12. [12]
  [12] G.L. Rouzoa, C. Lamourouxb, C. Bresson, et al., Hydrophilic interaction liquid chromatography for separation and quantification of selected room-temperature ionic liquids, J. Chromatogr. A 1164 (2007) 139-144.
13. [13]
  [13] C. Lamouroux, G. Foglia, G. Le Rouzo, How to separate ionic liquids: use of hydrophilic interaction liquid chromatography and mixed mode phases, J. Chromatogr. A 1218 (2011) 3022-3028.
14. [14]
  [14] M. Shi, Q.Y. Gao, J.M. Feng, Y.C. Lu, Analysis of inorganic cations in honey by capillary zone electrophoresis with indirect UV detection, J. Chromatogr. Sci. 50 (2012) 547-552.
15. [15]
  [15] G. Schill, E. Arvidsson, Application of indirect detection methods in biomedical analysis, J. Chromatogr. 492 (1989) 299-318.
16. [16]
  [16] X.H. Fan, Spectrophotometric determination of iron in agricultural samples with pyrogallol red in the presence of CPB, Technol. Dev. Chem. Ind. 31 (2002) 34-35.
17. [17]
  [17] L.N. Li, Z.K. Duan, H.Y. Zeng, Y.P. He, Q.Y. Chen, Determination of hexane in the acid cluster of caprolactam by high performance liquid chromatography with indirect photometric detection, Chin. J. Chromatogr. 29 (2011) 87-90.
18. [18]
  [18] Y. Polyakova, K.H. Row, Retention behaviour of N-CBZ-_D-phenylalanine and Dtryptophan: effect of ionic liquid as mobile-phase modifier, Acta Chromatogr. 17 (2006) 210-221.
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