Citation: Jin-Wu Zhao, Jing-Xiu Xu, Xiu-Zhen Guo. Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant[J]. Chinese Chemical Letters, ;2014, 25(11): 1499-1502. doi: 10.1016/j.cclet.2014.05.019 shu

Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant

1.
School of Pharmacy, Guangdong Medical College, Dongguan 523808, China

Corresponding author: Jin-Wu Zhao,
Received Date: 13 March 2014
Available Online: 5 May 2014
Fund Project: We thank Guangdong Medical College (No. XK1110) for financial support. (No. XK1110)

We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed, oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4- thiadiazole products.
- 1,2,4-Thiadizole,
- Thioamide,
- Water,
- Oxygen
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沈阳化工大学材料科学与工程学院沈阳 110142