Citation: Hong-Ping Long, Fu-Shuang Li, Kang-Ping Xu, Zhong-Bao Yang, Jing Li, Jun Peng, Gui-Shan Tan. Bioactive compounds from Selaginella involven Spring that protect PC-12 cells[J]. Chinese Chemical Letters, ;2014, 25(05): 805-808. doi: 10.1016/j.cclet.2014.03.024 shu

Bioactive compounds from Selaginella involven Spring that protect PC-12 cells

1.
a School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;
2.
b Xiangya Hospital of Central South University, Changsha 410008, China

Corresponding author: Gui-Shan Tan,
Received Date: 13 January 2014
Available Online: 4 March 2014
Fund Project: This research was supported by National Natural Science Foundation (No. 31370370) (No. 31370370) the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057) (No. 20100162110057)

Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8'S)-4,4',8-trihy-droxyl- 3,3'-dimethoxyl-9'-lignanolide (2) and a new natural product 4,4'-dihydroxyl-3,3',5,5'- dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2DNMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
- Selaginella,
- Selaginella involven Spring,
- Abietane diterpenoid,
- Lignans,
- PC-12 cell
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沈阳化工大学材料科学与工程学院沈阳 110142