Citation: Ali Taherkhani, Hassan Karimi-Maleh, Ali A. Ensafi, Hadi Beitollahi, Ahmad Hosseini, Mohammad A. Khalilzadeh, Hassan Bagheri. Simultaneous determination of cysteamine and folic acid in pharmaceutical and biological samples using modified multiwall carbon nanotubes paste electrode[J]. Chinese Chemical Letters, ;2012, 23(2): 237-240. doi: 10.1016/j.cclet.2011.10.023 shu

Simultaneous determination of cysteamine and folic acid in pharmaceutical and biological samples using modified multiwall carbon nanotubes paste electrode

a Department of Physics, Takestan Branch, Islamic Azad University, Takestan, Iran;
b Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran;
c Environment Department, Research Institute of Environmental Sciences, International Center for Science, High Technology and Environmental Sciences, Kerman, Iran;
d Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran;
e Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan, Iran

Received Date: 5 September 2011

Fund Project: The authors wish to thank Takestan, Majlesi and Qaemshahr Branch, Islamic Azad University, for their support.

A carbon paste electrode (CPE) chemically modified with multiwall carbon nanotubes and ferrocene (FC) was used as a selective electrochemical sensor for the simultaneous determination of trace amounts of cysteamine (CA) and folic acid (FA). This modified electrode showed very efficient electrocatalytic activity for the anodic oxidation of CA. The peaks current of differential pulse voltammograms of CA and FA increased linearly with their concentration in the ranges of 0.7-200 μmol/L CA and 5.0-700 μmol/L FA. The detection limits for CA and FA were 0.3 μmol/L and 2.0 μmol/L, respectively. The diffusion coefficient (D) and transfer coefficient (α) of CA were also determined. These conditions are sufficient to allow determination of CA and FA both individually and simultaneously.
- Cysteamine,
- Folic acid,
- Carbon nanotubes paste electrode,
- Voltammetry
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