Citation: Song Wei Tan, Hong Jun Wang, Ke Hua Tu, Hong Liang Jiang, Li Qun Wang. Ibuprofen induced drug loaded polymeric micelles[J]. Chinese Chemical Letters, ;2011, 22(9): 1123-1126. doi: 10.1016/j.cclet.2011.04.005 shu

Ibuprofen induced drug loaded polymeric micelles

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

Received Date: 22 December 2010

Fund Project: The work is financially supported by NSFC (No. 20674069).

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly (N-isopropylacrylamide). Only ibuprofen could induce the formation of drug loaded micelles, which was confirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly (N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found that the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.
- Micelle,
- Thermo-sensitive,
- Drug,
- Hydrogen-bonding,
- Poly (N-isopropylacrylamidc)
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