Citation: Hai Yang Liu, Kun Wang, Hai Yan Fu, Mao Lin Yuan, Hua Chen, Rui Xiang Li. Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions[J]. Chinese Chemical Letters, ;2011, 22(6): 738-740. doi: 10.1016/j.cclet.2010.12.048 shu

Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions

Key Lab of Green Chemistry and Technology, Ministry of Education, the Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064, China

Received Date: 15 October 2010

Amide, which is derived from proline and is inexpensive and air-stable, has been synthesized and characterized by ¹H NMR,¹³C NMR, and MS.It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction.In the Pd/amide catalytic system, aryl bromides can be coupled with phenylboronic acid in ethanol/water(1:2;v/v)in excellent yields even with a low Pd loading of 0.01 mol%.Moreover, the scope of the reaction is broad, and a wide variety of functional groups are tolerant.
- Suzuki cross-coupling,
- Palladium catalyst,
- Aryl bromides,
- Amide,
- Water
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