Citation: Li Hong Shen, Ya Li, Da Hai Zhang, Yi Sheng Lai, Li Jie Liu. Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent[J]. Chinese Chemical Letters, ;2011, 22(7): 768-770. doi: 10.1016/j.cclet.2010.12.037 shu

Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent

a Department of Chemistry, Handan College, Handan 056005, China;
b Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;
c Hebei Yiling Medicine Corporation Ltd., Shijiazhuang 050035, China

Received Date: 29 September 2010

To search for more potent antitumor agent, a series of novel nitric oxide-donating colchicine (Col) derivatives (6a-f, 8a and b) were synthesized by coupling nitrates with N-methyl colchiceinamide. Their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compounds 6c, 8a and 8b showed more potent cytotoxic activities than Col.
- Colchicine,
- N-methyl colchiceinamide,
- Nitrates,
- Cytotoxicity
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