Citation: Fang Xian Ning, Xiang Weng, Shi Liang Huang, Li Jun Gu, Zhi Shu Huang, Lian Quan Gu. A facile and efficient method for hydroxylation of azabenzanthrone compounds[J]. Chinese Chemical Letters, ;2011, 22(1): 41-44. doi: 10.1016/j.cclet.2010.09.010 shu

A facile and efficient method for hydroxylation of azabenzanthrone compounds

School of Pharmaceutical sciences, Sun Yat-Sen University, Guangzhou 51006, China

Received Date: 10 May 2010

Fund Project: We thanks the National Natural Science Foundation of China (No.30701050,20772159) and the NSFC/RGC Joimt Research Scheme (No.3073060006) for financial support for this study.

A novel and facile method of introducing 4-hydroxyl group into the aromatic ring of azabenzanthrone compounds was carded out by reacting azabenzanthrone compounds with hydrazine hydrate or hydroxylamine hydrochloride and sodium hydroxide in diethylene glycol(DEG) solvent.The mechanism of reaction may involve an amino intermediate and follow a hydroxyl substitution process.
- Azabenzaathrone,
- Hydroxylation,
- Hydrazine hydrate,
- Hydroxylamine hydrochloride,
- Sodium hydroxide
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