Citation: De Kai Yuan, Da Qiang Zhang, Ru Xing Li, Dao Quan Wang, Xin Ling Yang. Synthesis and anti-TMV activity of novel N-(pyrimidin-5-yl) N'-phenylureas[J]. Chinese Chemical Letters, ;2011, 22(1): 18-20. doi: 10.1016/j.cclet.2010.07.011 shu

Synthesis and anti-TMV activity of novel N-(pyrimidin-5-yl) N'-phenylureas

a Department of Applied Chemistry, Science College, China Agricultural University, Beijing 100191, China;
b Beijing Double-crane Pharmaceutical Co., Ltd., Beijing 100102, China

Received Date: 4 May 2010

Fund Project: No.20902107) and the Research Innovation Foundation of China Agricultural University (No.2006009). Also we show our thanks to Professor Zhijin Fan of Nankai University for his help in anti-TMV bioassay work.We are grateful to the the National 11th-Five-year Science and Technology Support Project on Pesticide Innovation (No.2006BAE01A01-1104),National Natural Science Foundation of China (No.20672138

In order to find novel leading structures of pesticide, a series of N-(pyrimidin-5-yl) N'-phenyinreas (4a-4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV (tobacco mosaic virus) activity. Two compounds (4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0×10^-4 g/mL.
- N-(Pyrimidin-5-yl)-N'-pbenylureas,
- Synthesis,
- Anti-TMV activity
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