Citation: Xin Qiu, Li Chuan Tang, Chao Qing Dong, Ji Cun Ren. Characterization of gold nanoparticle bioconjugation by resonance light scattering correlation spectroscopy[J]. Chinese Chemical Letters, ;2010, 21(10): 1227-1230. doi: 10.1016/j.cclet.2010.05.007 shu

Characterization of gold nanoparticle bioconjugation by resonance light scattering correlation spectroscopy

College of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai 200240, China

Received Date: 18 January 2010

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No.20975067),RFDP (No.20090073120039) and Shanghai Educational Development Foundation (No.2008CG12).

Gold nanoparticles (GNPs) have been widely used as probes and nanomaterials in certain biological and biomedical fields thanks to its special physical and chemical properties. However, it is still difficult to characterize GNPs-bioconjugates in solution, which has greatly limited further bioapplications of GNPs. In this study, we reported a single particle method for characterizing GNPsbiomolecules in solution using resonance light scattering correlation spectroscopy (RLSCS). The interaction of GNPs with bovine serum albumin (BSA) and thiol-modified oligonucletides were investigated.
- Resonance light scattering correlation spectroscopy,
- Gold nanoparticle,
- Interaction,
- Biomolecules
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