Citation: Guo Xia Li, Xiang Qin Lin. A glass nanopore electrode for single molecule detection[J]. Chinese Chemical Letters, ;2010, 21(9): 1115-1118. doi: 10.1016/j.cclet.2010.04.026 shu

A glass nanopore electrode for single molecule detection

Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

Received Date: 28 December 2009

Fund Project: We gratefully acknowledge the financial support from the National Natural Science Foundation of China (No.20575062) and The Graduate Innovation Fund of USTC.

We have developed a simple method for fabricating robust and low noise glass nanopore electrodes with pore size 10±5 nm to detect single molecules. β-Cyclodextrin was used as model compound for characterization. In 1.0 mol/L NaCl solution, the molecules generated current pulses of 2-5 pA with noise level less than 0.8 pA. A slide mode and a plug mode were suggested for the way of β-cyclodextrin single molecule moving into the glass nanopores.
- Glass nanopores,
- Single molecule detecting,
- β-Cyclodextrin
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