Citation: Yang Dong, Hong Zhuo Liu, Lu Xu, Gang Li, Zi Ning Ma, Fei Han, Hui Min Yao, Yan Hui Sun, San Ming Li. A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing[J]. Chinese Chemical Letters, ;2010, 21(8): 1011-1014. doi: 10.1016/j.cclet.2010.04.010 shu

A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing

Yang Dong ^a, ,
Hong Zhuo Liu ^a ,
Lu Xu ^a ,
Gang Li ^a ,
Zi Ning Ma ^b ,
Fei Han ^a ,
Hui Min Yao ^a ,
Yan Hui Sun ^a ,
San Ming Li ^a

a School of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China;
b China Criminal Police University, Shenyang 110035, China

Received Date: 18 December 2009

A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCI (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application.
- Chitosan,
- Alginate,
- Composite membrane,
- Ciprofloxacin HCI,
- Sustained release,
- Antimicrobial efficacy
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