Citation: Cherkupally Sanjeeva Reddy, L. Sanjeeva Rao, M. Vani Devi, G. Rajesh Kumar, A. Nagaraj. Synthesis of some new 3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones as antimicrobials[J]. Chinese Chemical Letters, ;2010, 21(9): 1945-1048. doi: 10.1016/j.cclet.2010.03.018 shu

Synthesis of some new 3-[5-(2-oxo-2H-3-chromenyl)-1,3-oxazol-2-yl]-1,3-thiazolan-4-ones as antimicrobials

a Department of Chemistry, Kakatiya University, Warangal 506 009, India;
b Department of Pharmaceutical Chemistry, Telangana University, Nizamabad 503 175, India

Received Date: 4 January 2010

Fund Project: The authors are grateful to the Director,Indian Institute of Chemical Technology,Hyderabad,India,for providing NMR and Mass Spectral Data.Financial assistance from the UGC SAP (Phase-I)-DRS Programme,New Delhi,India,is greatly acknowledged.

A series of some new 2-imino-5-[(Z)-1-(4-methylphenyl) methylidene]-3-[5-(2-oxo-2H-3-chromenyl)-1, 3-oxazol-2-yl]-1, 3-thiazolan-4-ones 5a-j has been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz. Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 6538p) and Micrococcus luteus (IFC 12708), and Gram-negative bacteria viz. Proteus vulgaris(ATCC 3851), Salmonella typhimurium(ATCC 14028) and Escherichia coli(ATCC 25922). Among the screened compounds, 5d, 5e, 5f, 5g, and 5j exhibited potent inhibitory activity compared to standard drug, and emerged as potential molecules for further development.
- 1,3-Thiazolan-4-ones,2-Oxo-2H-chromenyl,
- 1,3-Oxazolyl,
- Antibacterial activity
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