Citation: Guo Qiang Hu, Zhong Quan Zhang, Song Qiang Xie, Wen Long Huang. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole[J]. Chinese Chemical Letters, ;2010, 21(6): 661-663. doi: 10.1016/j.cclet.2010.01.037 shu

Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I):Tethered with a fused heterocyclic s-triazolo [2,1-b] [1,3,4]thiadiazole

a Institute of Chemistry & Biology, Henan University, Kaifeng 475001, China;
b China Pharmaceutical University, Nanjing 210009, China

Received Date: 8 September 2009

Fund Project: This project was supported by National Natural Science Foundation of China (No. 20872028).

Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b] [1,3,4]thiadiazole derived from antibacterial quinolones were synthesized and characterized, and their in vitro antitumor activity against L1210, CHO cell lines was evaluated via the respective IC₅₀ values.
- Fluoroquinolone,
- Dirtier,
- Antitumor evaluation
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