Citation: Hai Qian, Wei Chen, Jin Pei Zhou, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method[J]. Chinese Chemical Letters, ;2010, 21(4): 388-390. doi: 10.1016/j.cclet.2009.12.016 shu

Total synthesis of endothelin 1 by microwave-assisted solid phase method

a Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;
b Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 17 August 2009

Fund Project: The work was supported by the key project of Chinese Ministry of Education (No. 109086).

A microwave-assisted solid phase synthesis for endothelin 1 is presented.Reduced endothelin 1 was synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal protection strategy.The whole peptide was cleaved from the resin and two disulphide bridges were formed under air oxidation at room temperature.The purity and efficiency of synthesizing the peptide is much higher than other methods used before.
- Endothelin 1,
- Microwave irradiation,
- Solid phase,
- Disulphide bridge
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