Citation: Xiang Liu, Zheng Guang Pan, Jian He Xu, He Xing Li. Enantioselective reduction of acetophenone analogues using carrot and celeriac enzymes system[J]. Chinese Chemical Letters, ;2010, 21(3): 305-308. doi: 10.1016/j.cclet.2009.11.019 shu

Enantioselective reduction of acetophenone analogues using carrot and celeriac enzymes system

a School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China;
b State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;
c Department of Chemistry, Shanghai Normal University, Shanghai 200234, China

Received Date: 17 August 2009

Fund Project: This research was financially supported by the National Natural Science Foundation of China (No. 20672037), and the National Special Fund for State Key Laboratory of Bioreactor Engineering (No. 2060204).

The enantioselective reduction of acetophenone analogues catalyzed by carrot and celeriac was performed in moderate conversions and excellent enantiomeric excesses. The steric factors and electronic effects of the substituents at the aromatic ring were found to significantly affect the efficiency of the enantioselective reduction of acetophenone analogues, while they had a little effect on the enantioselectivity of aeetophenone analogues reduction. It was also found that the conversions of acetophenone analogues reduction at 33℃ by means of both biocatalysts were three times as great as those at room temperature.
- Enantioselective reduction,
- Acetophenone analogues,
- Plant cells,
- Biocatalysis
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