Citation: Pei Hua Shang, Chang Mei Cheng, Hua Wang, Hong Chao Zheng, Yu Fen Zhao. Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine[J]. Chinese Chemical Letters, ;2010, 21(2): 131-134. doi: 10.1016/j.cclet.2009.10.017 shu

Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine

Key Laboratory of Phosphorus and Chemical Biology, the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 10084, China

Received Date: 21 May 2009

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20872078) and the Basic Science Research Foundation of Tsinghua University (No. JC 2001046).

An efficient and novel method for synthesizing 3',5'-dithio-2'-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2'-O-tosyiguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
- 3',5'-Dithio-2'-deoxyguanosine,
- Guanosine,
- Synthesis
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