Citation: Hui Zhu, Ri Fang Yang, Liu Hong Yun, Jin Li. Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation[J]. Chinese Chemical Letters, ;2010, 21(1): 35-38. doi: 10.1016/j.cclet.2009.09.012 shu

Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation

Beijing Institute of Pharmacology and Toxicology, Department of Medicinal Chemistry, Beijing 100850, China

Received Date: 13 May 2009

Fund Project: We wish to thank the National Basic Research Program (No. 2003CB515400), administered by the Ministry of Science and Technology of China.

A facile and efficient method for the preparation of 2-non-substituted quinoline-4-carboxylic acids is described via the Pfitzinger reaction of isatins with sodium pyruvate following consequent decarboxylation under microwave irradiation.
- Quinoline-4-carboxylic acids,
- Pfitzinger reaction,
- Microwave irradiation
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