Citation: Yan Wei Hu, Li Zuo, De Yong Ye, Wen Hu Duan. Selective debenzylation of benzyl esters by silica-supported sodium hydrogen sulphate[J]. Chinese Chemical Letters, ;2009, 20(10): 1157-1160. doi: 10.1016/j.cclet.2009.04.028 shu

Selective debenzylation of benzyl esters by silica-supported sodium hydrogen sulphate

Yan Wei Hu ^a, ,
Li Zuo ^b ,
De Yong Ye ^a ,
Wen Hu Duan ^b,c

a Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China;
b Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
c Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China

Received Date: 17 February 2009

Fund Project: We are grateful for financial support from National Science Foundation of China (Nos.03772648 and 30721005) and Knowledge Innovation Program of the Chinese Academy of Sciences (No.06G8031014).

A new debenzylation of benzyl esters by silica-supported sodium hydrogen sulfate is described.The debenzylation could be achieved selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro,unsaturated bonds, and ethyl ester.
- Debenzylation,
- Benzyl esters,
- Silica-supported sodium hydrogen sulphate
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