Citation: Ke Xin Huang, Yu Bing Feng, Wei Yao, Lei Xiang Yang, Feng Wang, Hai Bo Li, Su Zeng, Jing Xu Gong, Ming Hui Hu, Yu Zhao, Xiu Mei Wu, Xiao Kun Li, Jia Qu. Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols[J]. Chinese Chemical Letters, ;2009, 20(10): 1187-1190. doi: 10.1016/j.cclet.2009.04.026 shu

Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols

Ke Xin Huang ^a, ,
Yu Bing Feng ^b ,
Wei Yao ^a,c ,
Lei Xiang Yang ^b ,
Feng Wang ^b ,
Hai Bo Li ^b,d ,
Su Zeng ^b ,
Jing Xu Gong ^b ,
Ming Hui Hu ^b ,
Yu Zhao ^b ,
Xiu Mei Wu ^a ,
Xiao Kun Li ^a ,
Jia Qu ^a

a Key Laboratory of Southern Zhejiang TCM R&D, Pharmacy School of Wenzhou Medical College, Wenzhou 325035, China;
b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;
c Zhejiang Chemical Industry Research Institute, Zhejiang Chem-Tech Group Co., Ltd., Hangzhou 310023, China;
d College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, FL 32307, USA

Received Date: 2 March 2009

Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3-6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7-8)were designed and synthesized.Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O₂^·-.free radicals, as well as by measuring their inhibitory ability against LPO.Both the 2,3-trans and the 2,3-cis conformers exhibited certain quenching abilities to DPPH and O₂^·- radicals, while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO.
- 5,6,7-Trimethoxy-2,3-dihydroflavonols,
- cis-Dihydroflavonols,
- Antioxidant,
- Lipid peroxidation,
- Free radical scavenger
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