Citation: Lei Chen, Jin Jiang Wang, c, Hong Tao Song, Guo Gang Zhang, Lu Ping Qin. New cytotoxic cerebroside from Gynura divaricata[J]. Chinese Chemical Letters, ;2009, 20(9): 1091-1093. doi: 10.1016/j.cclet.2009.04.021 shu

New cytotoxic cerebroside from Gynura divaricata

a Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;
b Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
c School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 29 December 2008

Fund Project: China.This work was supported by the Scientific Research Fund of Fujian Provincial Department of Science & Technology (No.2008Y0086) and the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau (No.wzy0606)

A new cerebroside, gynuraoside (1), was isolated from the aerial parts of Gynura divaricataDC. It was determined to be 1-O-β- D-glucopyranosyl-(2S,3S,4R,10E)-2-[(2'R)-2'-hydroxyldocosanoyl-amino]-10-octadecene-1,3,4-triol on the basis of chemical and spectroscopic evidence. This compound showed strong cytotoxicity against L1210 leukemia cell line in vitro.
- Gynura divaricata,
- Cerebroside,
- Cytotoxicity
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