Citation: Ali Reza Kiasat Roya Mirzajani, Haji Shalbaf, Tahereh Tabatabaei. Nuclephilic ring opening of epoxides promoted by multi-site phase-transfer catalyst:An efficient and eco-friendly route to synthesis of b-hydroxy-thiocyanate[J]. Chinese Chemical Letters, ;2009, 20(9): 1026-1029. doi: 10.1016/j.cclet.2009.04.015 shu

Nuclephilic ring opening of epoxides promoted by multi-site phase-transfer catalyst:An efficient and eco-friendly route to synthesis of b-hydroxy-thiocyanate

Chemistry Department, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, Iran

Received Date: 4 January 2009

A highly effective and mild protocol for ring opening of epoxides with NH ₄ SCN in the presence of catalytic amount of a multisite phase-transfer catalyst, α,α',α" -N-hexakis(triethylammoniummethylene chloride)-melamine, is developed. A variety of b-hydroxy thiocyanates as important intermediates in agricultural and pharmaceutical chemistry were obtained in high yields with excellent regioselectivity and in short reaction times.
- Multi-site phase-transfer catalyst,
- β-Hydroxythiocyanate,
- Thiocyanohydrin,
- Epoxide,
- Ring opening,
- Regioselectivity
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