Citation: Zhong Lv Zhang, Zhi Jie Sun, Fei Xue, Xian Jin Luo, Nai Yun Xiu, Li Teng, Zong Gen Peng. Design,synthesis and biological activity of some novelbenzimidazole derivatives against Coxsackie virus B₃[J]. Chinese Chemical Letters, ;2009, 20(8): 921-923. doi: 10.1016/j.cclet.2009.03.035 shu

Design,synthesis and biological activity of some novelbenzimidazole derivatives against Coxsackie virus B₃

a School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China;
b School of Life Science and Environmental Science, Shanghai Normal University, Shanghai 200234, PR China;
c Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, PR China

Received Date: 8 December 2008

A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B₃(CVB₃) activity was evaluated in VERO cells. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin (RBV) with IC₅₀ values of 5.30 and 1.06 μg/mL, respectively.
- Benzimidazole,
- Coxsackie virus B₃(CVB₃),
- Furan,
- Anti-CVB₃ activity
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