Citation: Di Zao Li, Zhong Fei Zheng, Zhi Yun Kang, De Quan Yu. A new method for preparing (2Z, 4Z, 6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues[J]. Chinese Chemical Letters, ;2009, 20(6): 635-639. doi: 10.1016/j.cclet.2009.02.011 shu

A new method for preparing (2Z, 4Z, 6Z)-diethyl-4,5-oxepinedicarboxylates and some 1H-azepine analogues

The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Received Date: 27 October 2008

Fund Project: The National Natural Science Foundation of China (No.20372086) supported this work.

A new method for preparing (2Z, 4Z, 6Z)-4,5-diethyloxepinedicarboxylate by one-step is described. The synthesis of several oxepines and azepines derivatives was carried out by the reaction of substituted furans or pyrroles with diethyl acetylenedicarboxylate in boiling toluene. The effect factors for this reaction were discussed and reaction condition was optimized.
- Acetylenedicarboxylate,
- Furans,
- Pyrroles,
- Cycloaddition,
- Oxepine,
- Azepine
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