Citation: Shan Qian, Xiao Juan Ye, Fan Zheng, Li Yang, Yong Wu. Synthesis of (S) and (R)-tilisolol hydrochloride[J]. Chinese Chemical Letters, ;2009, 20(6): 648-650. doi: 10.1016/j.cclet.2008.12.048 shu

Synthesis of (S) and (R)-tilisolol hydrochloride

Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China

Received Date: 27 October 2008

Fund Project: This work was supported by the National Natural Science Foundation of China (No.30672537).

Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, 1a and 1b were synthesized from inexpensive phthalic anhydride 2 in eight steps with 13% (S) and 15% (R) overall yield.
- Tilisolol hydrochloride,
- Optical,
- Synthesis
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